Reactome | GPVI-mediated activation cascade

Schema > Pathway > Entries

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107052
displayName	GPVI-mediated activation cascade
eventOf	[Pathway:R-SCE-76002] Platelet activation, signaling and aggregation - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-SCE-429497] SLP-76 stimulates PLC gamma 2 - Saccharomyces cerevisiae [Reaction:R-SCE-114689] PLC gamma 2-mediated PIP2 hydrolysis - Saccharomyces cerevisiae [Reaction:R-SCE-2316429] PIP3 recruits PDPK1 to the membrane - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GPVI-mediated activation cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-114604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SCE-76002] Platelet activation, signaling and aggregation
(inferredTo)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade

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