Reactome | SLP-76 stimulates PLC gamma 2

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SLP-76 stimulates PLC gamma 2 Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:429489] Jupe, S, 2009-07-16
dbId	429497
displayName	SLP-76 stimulates PLC gamma 2
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
eventOf	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-114601] PLCG2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429488] Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets [LiteratureReference:429494] Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2 [LiteratureReference:429495] Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLP-76 stimulates PLC gamma 2
orthologousEvent	[BlackBoxEvent:R-PFA-429497] SLP-76 stimulates PLC gamma 2 - Plasmodium falciparum [BlackBoxEvent:R-SCE-429497] SLP-76 stimulates PLC gamma 2 - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-429497] SLP-76 stimulates PLC gamma 2 - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-429497] SLP-76 stimulates PLC gamma 2 - Dictyostelium discoideum [BlackBoxEvent:R-CEL-429497] SLP-76 stimulates PLC gamma 2 - Caenorhabditis elegans [BlackBoxEvent:R-DME-429497] SLP-76 stimulates PLC gamma 2 - Drosophila melanogaster [BlackBoxEvent:R-GGA-429497] SLP-76 stimulates PLC gamma 2 - Gallus gallus [BlackBoxEvent:R-XTR-429497] SLP-76 stimulates PLC gamma 2 - Xenopus tropicalis [BlackBoxEvent:R-SSC-429497] SLP-76 stimulates PLC gamma 2 - Sus scrofa [BlackBoxEvent:R-BTA-429497] SLP-76 stimulates PLC gamma 2 - Bos taurus [BlackBoxEvent:R-CFA-429497] SLP-76 stimulates PLC gamma 2 - Canis familiaris [BlackBoxEvent:R-RNO-429497] SLP-76 stimulates PLC gamma 2 - Rattus norvegicus [BlackBoxEvent:R-MMU-429497] SLP-76 stimulates PLC gamma 2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-114602] p-PLCG2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-429449] Syk activation leads to SLP-76 activation - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-9032140] Positive regulation by 'p-Y113,128,145-LCP2 [cytosol]'
regulationReference	[RegulationReference:9642267] Positive regulation by 'p-Y113,128,145-LCP2 [cytosol]' Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-429497
summation	[Summation:429492] SLP-76 has a well-established role in recruitment of PLC gam...
updateTrackers	[UpdateTracker:9791211] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v32:[add_removeInput, add_removeOutput] [UpdateTracker:9779855] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v64:[addRegulator, removeInput, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9791211] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v32:[add_removeInput, add_removeOutput] [UpdateTracker:9779855] Update Tracker - [BlackBoxEvent:429497] SLP-76 stimulates PLC gamma 2 - v64:[addRegulator, removeInput, removeOutput]
(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis

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