Reactome | GPVI-mediated activation cascade

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GPVI-mediated activation cascade Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443404
displayName	GPVI-mediated activation cascade
eventOf	[Pathway:R-BTA-76002] Platelet activation, signaling and aggregation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-114600] Fyn/Lyn-mediated phosphorylation of FcR1 gamma - Bos taurus [Reaction:R-BTA-139842] Binding of Syk tyrosine kinase - Bos taurus [Reaction:R-BTA-453200] SYK autophosphorylates - Bos taurus [Reaction:R-BTA-453183] p-Y348-SYK dissociates - Bos taurus [Reaction:R-BTA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Bos taurus [Reaction:R-BTA-442291] VAV2 is a GEF for Rho/Rac family kinases - Bos taurus [Reaction:R-BTA-442314] VAV3 is a GEF for Rho/Rac family kinases - Bos taurus [Reaction:R-BTA-434836] Syk/Lck phosphorylate LAT - Bos taurus [Reaction:R-BTA-429449] Syk activation leads to SLP-76 activation - Bos taurus [BlackBoxEvent:R-BTA-429497] SLP-76 stimulates PLC gamma 2 - Bos taurus [Reaction:R-BTA-430158] p-SLP-76 binds VAV - Bos taurus [Reaction:R-BTA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Bos taurus [BlackBoxEvent:R-BTA-437118] GPVI stimulates PI3K beta, gamma - Bos taurus [Reaction:R-BTA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Bos taurus [Reaction:R-BTA-2316429] PIP3 recruits PDPK1 to the membrane - Bos taurus [Reaction:R-BTA-5684169] G6B binds PTPN6,PTPN11 - Bos taurus [Reaction:R-BTA-5684836] CLEC1B dimer binds PDPN - Bos taurus [BlackBoxEvent:R-BTA-5684806] Unknown kinase phosphorylates CLEC1B dimer:PDPN - Bos taurus [Reaction:R-BTA-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK - Bos taurus
inferredFrom	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GPVI-mediated activation cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-114604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-76002] Platelet activation, signaling and aggregation
(inferredTo)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade

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