Reactome | PDPK1 activates PRKCZ

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PDPK1 activates PRKCZ Show undefined attributes

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:437273] 3-phosphoinositide-dependent protein kinase activity of PDPK1:PIP3:PRKCZ [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:437182] Jupe, S, 2009-09-11
dbId	437195
displayName	PDPK1 activates PRKCZ
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
eventOf	[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ - Homo sapiens [Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Homo sapiens
inferredFrom	[Reaction:R-RNO-437185] PDK1 activates PKC zeta - Rattus norvegicus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-437191] PDPK1:PIP3:PRKCZ [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:437190] Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PDPK1 activates PRKCZ
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
precedingEvent	[Reaction:R-HSA-437192] PDPK1 binds PRKCZ - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-437195
summation	[Summation:437262] 3-phosphoinositide dependent protein kinase-1 (Pdpk1, also k...
updateTrackers	[UpdateTracker:9777988] Update Tracker - [Reaction:437195] PDPK1 activates PRKCZ - v68:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777988] Update Tracker - [Reaction:437195] PDPK1 activates PRKCZ - v68:[modifyText]
(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade [Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ
(precedingEvent)	[Reaction:R-HSA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation
(inferredTo)	[Reaction:R-RNO-437185] PDK1 activates PKC zeta

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