Reactome | Syk activation leads to SLP-76 activation

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Syk activation leads to SLP-76 activation Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:9032137] protein tyrosine kinase activity of p-Y348-SYK [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:429457] Jupe, S, 2009-07-15
dbId	429449
displayName	Syk activation leads to SLP-76 activation
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03 [InstanceEdit:9032138] Orlic-Milacic, Marija, 2017-12-06
eventOf	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-430158] p-SLP-76 binds VAV - Homo sapiens [Reaction:R-HSA-430190] p-SLP-76 binds NCK - Homo sapiens [BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-202306] LCP2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429454] Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets [LiteratureReference:9032127] Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein [LiteratureReference:9032128] Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes [LiteratureReference:9032249] Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Syk activation leads to SLP-76 activation
orthologousEvent	[Reaction:R-GGA-429449] Syk activation leads to SLP-76 activation - Gallus gallus [Reaction:R-XTR-429449] Syk activation leads to SLP-76 activation - Xenopus tropicalis [Reaction:R-DRE-429449] Syk activation leads to SLP-76 activation - Danio rerio [Reaction:R-SSC-429449] Syk activation leads to SLP-76 activation - Sus scrofa [Reaction:R-BTA-429449] Syk activation leads to SLP-76 activation - Bos taurus [Reaction:R-CFA-429449] Syk activation leads to SLP-76 activation - Canis familiaris [Reaction:R-RNO-429449] Syk activation leads to SLP-76 activation - Rattus norvegicus [Reaction:R-MMU-429449] Syk activation leads to SLP-76 activation - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-202175] p-Y113,128,145-LCP2 [cytosol]
precedingEvent	[Reaction:R-HSA-453183] p-Y348-SYK dissociates - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445650] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
revised	[InstanceEdit:9032138] Orlic-Milacic, Marija, 2017-12-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429449
summation	[Summation:429448] Stimulation of platelets with collagen-related peptide leads...
updateTrackers	[UpdateTracker:9779895] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v64:[addCatalystActivity, addLiteratureReference, modifyText, removeInput, removeOutput] [UpdateTracker:9790903] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v32:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779895] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v64:[addCatalystActivity, addLiteratureReference, modifyText, removeInput, removeOutput] [UpdateTracker:9790903] Update Tracker - [Reaction:429449] Syk activation leads to SLP-76 activation - v32:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-HSA-430158] p-SLP-76 binds VAV [Reaction:R-HSA-430190] p-SLP-76 binds NCK [BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2

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