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Schema
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Reaction
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Entries
VAV1 is a GEF for Rho/Rac family GTPases
Show undefined attributes
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authored
[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity
[CatalystActivity:442279] guanyl-nucleotide exchange factor activity of p-Y174-VAV1 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:442288] Jupe, S, 2009-09-24
dbId
442273
displayName
VAV1 is a GEF for Rho/Rac family GTPases
edited
[InstanceEdit:435388] Jupe, S, 2009-09-09
eventOf
[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-114543] VAV1 Rho/Rac effectors:GDP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:389291] Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
[LiteratureReference:442301] Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
VAV1 is a GEF for Rho/Rac family GTPases
orthologousEvent
[Reaction:R-CEL-442273] VAV1 is a GEF for Rho/Rac family GTPases - Caenorhabditis elegans
[Reaction:R-DME-442273] VAV1 is a GEF for Rho/Rac family GTPases - Drosophila melanogaster
[Reaction:R-XTR-442273] VAV1 is a GEF for Rho/Rac family GTPases - Xenopus tropicalis
[Reaction:R-SSC-442273] VAV1 is a GEF for Rho/Rac family GTPases - Sus scrofa
[Reaction:R-BTA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Bos taurus
[Reaction:R-CFA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Canis familiaris
[Reaction:R-RNO-442273] VAV1 is a GEF for Rho/Rac family GTPases - Rattus norvegicus
[Reaction:R-MMU-442273] VAV1 is a GEF for Rho/Rac family GTPases - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-114539] VAV1 Rho/Rac effectors:GTP [cytosol]
precedingEvent
[Reaction:R-HSA-437936] p-Y348-SYK phosphorylates VAV family - Homo sapiens
[Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-8874423] Negative regulation by 'VAV family:PIP2 [plasma membrane]'
[PositiveRegulation:R-HSA-8874424] Positive regulation by 'PIP3:VAV1,2,3 [plasma membrane]'
releaseDate
2010-09-21
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-442273
summation
[Summation:442297] Vav family members are guanine nucleotide exchange factors (...
Referrals
(hasEvent)
[Pathway:R-HSA-114604] GPVI-mediated activation cascade
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