Reactome | VAV1 is a GEF for Rho/Rac family GTPases

Schema > Reaction > Entries

VAV1 is a GEF for Rho/Rac family GTPases Show undefined attributes

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:442279] guanyl-nucleotide exchange factor activity of p-Y174-VAV1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:442288] Jupe, S, 2009-09-24
dbId	442273
displayName	VAV1 is a GEF for Rho/Rac family GTPases
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-114543] VAV1 Rho/Rac effectors:GDP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389291] Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product [LiteratureReference:442301] Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	VAV1 is a GEF for Rho/Rac family GTPases
orthologousEvent	[Reaction:R-CEL-442273] VAV1 is a GEF for Rho/Rac family GTPases - Caenorhabditis elegans [Reaction:R-DME-442273] VAV1 is a GEF for Rho/Rac family GTPases - Drosophila melanogaster [Reaction:R-GGA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Gallus gallus [Reaction:R-XTR-442273] VAV1 is a GEF for Rho/Rac family GTPases - Xenopus tropicalis [Reaction:R-SSC-442273] VAV1 is a GEF for Rho/Rac family GTPases - Sus scrofa [Reaction:R-BTA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Bos taurus [Reaction:R-CFA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Canis familiaris [Reaction:R-RNO-442273] VAV1 is a GEF for Rho/Rac family GTPases - Rattus norvegicus [Reaction:R-MMU-442273] VAV1 is a GEF for Rho/Rac family GTPases - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-114539] VAV1 Rho/Rac effectors:GTP [cytosol]
precedingEvent	[Reaction:R-HSA-437936] p-Y348-SYK phosphorylates VAV family - Homo sapiens [Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8874423] Negative regulation by 'VAV family:PIP2 [plasma membrane]' [PositiveRegulation:R-HSA-8874424] Positive regulation by 'PIP3:VAV1,2,3 [plasma membrane]'
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-442273
summation	[Summation:442297] Vav family members are guanine nucleotide exchange factors (...
updateTrackers	[UpdateTracker:9782895] Update Tracker - [Reaction:442273] VAV1 is a GEF for Rho/Rac family GTPases - v58:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9782895] Update Tracker - [Reaction:442273] VAV1 is a GEF for Rho/Rac family GTPases - v58:[addRegulator]
(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade