Reactome | Platelet activation, signaling and aggregation

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Platelet activation, signaling and aggregation Show undefined attributes

authored	[InstanceEdit:140345] de Bono, B, 2004-08-13 07:29:26
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId	76002
displayName	Platelet activation, signaling and aggregation
eventOf	[TopLevelPathway:R-HSA-109582] Hemostasis - Homo sapiens
figure	[Figure:9628940] /figures/ehld/R-HSA-76002.svg
goBiologicalProcess	[GO_BiologicalProcess:20684] platelet activation
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-430116] GP1b-IX-V activation signalling - Homo sapiens [Pathway:R-HSA-392518] Signal amplification - Homo sapiens [Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Homo sapiens [Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens [Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation) - Homo sapiens [Pathway:R-HSA-114508] Effects of PIP2 hydrolysis - Homo sapiens [Pathway:R-HSA-76005] Response to elevated platelet cytosolic Ca2+ - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:1381793] Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets [LiteratureReference:1381815] GPIIb-IIIa: the responsive integrin [LiteratureReference:140151] Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation [LiteratureReference:870224] Nucleotide receptor signaling in platelets [LiteratureReference:870200] Platelet purinergic receptors [LiteratureReference:866441] Platelets in atherothrombosis [LiteratureReference:870247] Resistance to thromboembolism in PI3Kgamma-deficient mice [LiteratureReference:870212] Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
maxDepth	5
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Platelet activation, signaling and aggregation
orthologousEvent	[Pathway:R-MMU-76002] Platelet activation, signaling and aggregation - Mus musculus [Pathway:R-RNO-76002] Platelet activation, signaling and aggregation - Rattus norvegicus [Pathway:R-CFA-76002] Platelet activation, signaling and aggregation - Canis familiaris [Pathway:R-BTA-76002] Platelet activation, signaling and aggregation - Bos taurus [Pathway:R-SSC-76002] Platelet activation, signaling and aggregation - Sus scrofa [Pathway:R-DRE-76002] Platelet activation, signaling and aggregation - Danio rerio [Pathway:R-XTR-76002] Platelet activation, signaling and aggregation - Xenopus tropicalis [Pathway:R-GGA-76002] Platelet activation, signaling and aggregation - Gallus gallus [Pathway:R-DME-76002] Platelet activation, signaling and aggregation - Drosophila melanogaster [Pathway:R-CEL-76002] Platelet activation, signaling and aggregation - Caenorhabditis elegans [Pathway:R-DDI-76002] Platelet activation, signaling and aggregation - Dictyostelium discoideum [Pathway:R-SPO-76002] Platelet activation, signaling and aggregation - Schizosaccharomyces pombe [Pathway:R-SCE-76002] Platelet activation, signaling and aggregation - Saccharomyces cerevisiae [Pathway:R-PFA-76002] Platelet activation, signaling and aggregation - Plasmodium falciparum
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
revised	[InstanceEdit:870287] Jupe, S, 2010-06-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-76002
summation	[Summation:140348] Platelet activation begins with the initial binding of adhes...
updateTrackers	[UpdateTracker:9790800] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v33:[modifyText, removeHasEvent, updateContainedPathway] [UpdateTracker:9777285] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v72:[updateContainedPathway] [UpdateTracker:9780377] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v63:[updateContainedPathway] [UpdateTracker:9791467] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v30:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784787] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v53:[updateIndirectRLE] [UpdateTracker:9778420] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v68:[updateIndirectRLE] [UpdateTracker:9777434] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v71:[updateContainedPathway] [UpdateTracker:9787952] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v44:[updateIndirectRLE] [UpdateTracker:9776387] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v76:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789489] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v38:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedPathway] [UpdateTracker:9784148] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v54:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789571] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v37:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791484] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v29:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783261] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v57:[updateContainedPathway] [UpdateTracker:9789030] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v39:[updateContainedPathway] [UpdateTracker:9791913] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v25:[updateContainedPathway] [UpdateTracker:9853275] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v87:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9786669] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782982] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v58:[updateIndirectRLE] [UpdateTracker:9779972] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v64:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788870] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v40:[updateContainedPathway] [UpdateTracker:9775661] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v78:[updateIndirectRLE] [UpdateTracker:9790311] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v34:[addHasEvent, modifyText, updateContainedPathway] [UpdateTracker:9774816] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v81:[updateContainedPathway] [UpdateTracker:9783999] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v55:[updateContainedPathway] [UpdateTracker:9782644] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v59:[updateIndirectRLE] [UpdateTracker:9790973] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v32:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)

[TopLevelPathway:R-HSA-109582] Hemostasis

(updatedInstance)

[UpdateTracker:9790800] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v33:[modifyText, removeHasEvent, updateContainedPathway]
[UpdateTracker:9777285] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v72:[updateContainedPathway]
[UpdateTracker:9780377] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v63:[updateContainedPathway]
[UpdateTracker:9791467] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v30:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784787] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v53:[updateIndirectRLE]
[UpdateTracker:9778420] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v68:[updateIndirectRLE]
[UpdateTracker:9777434] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v71:[updateContainedPathway]
[UpdateTracker:9787952] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v44:[updateIndirectRLE]
[UpdateTracker:9776387] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v76:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9789489] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v38:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9784148] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v54:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9789571] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v37:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791484] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v29:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9783261] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v57:[updateContainedPathway]
[UpdateTracker:9789030] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v39:[updateContainedPathway]
[UpdateTracker:9791913] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v25:[updateContainedPathway]
[UpdateTracker:9853275] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v87:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9786669] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v49:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9782982] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v58:[updateIndirectRLE]
[UpdateTracker:9779972] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788870] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v40:[updateContainedPathway]
[UpdateTracker:9775661] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v78:[updateIndirectRLE]
[UpdateTracker:9790311] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v34:[addHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9774816] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v81:[updateContainedPathway]
[UpdateTracker:9783999] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v55:[updateContainedPathway]
[UpdateTracker:9782644] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v59:[updateIndirectRLE]
[UpdateTracker:9790973] Update Tracker - [Pathway:76002] Platelet activation, signaling and aggregation - v32:[updateContainedPathway, updateIndirectRLE]

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