Reactome | HCYS [cytosol]

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HCYS [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-SCE-1614631] Homocysteine is degraded to oxobutanoate and H2S - Saccharomyces cerevisiae [Reaction:R-SPO-1614631] Homocysteine is degraded to oxobutanoate and H2S - Schizosaccharomyces pombe [Reaction:R-DDI-1614631] Homocysteine is degraded to oxobutanoate and H2S - Dictyostelium discoideum [Reaction:R-CEL-1614631] Homocysteine is degraded to oxobutanoate and H2S - Caenorhabditis elegans [Reaction:R-DME-1614631] Homocysteine is degraded to oxobutanoate and H2S - Drosophila melanogaster [Reaction:R-GGA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Gallus gallus [Reaction:R-XTR-1614631] Homocysteine is degraded to oxobutanoate and H2S - Xenopus tropicalis [Reaction:R-DRE-1614631] Homocysteine is degraded to oxobutanoate and H2S - Danio rerio [Reaction:R-SSC-1614631] Homocysteine is degraded to oxobutanoate and H2S - Sus scrofa [Reaction:R-BTA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Bos taurus [Reaction:R-CFA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Canis familiaris [Reaction:R-RNO-1614631] Homocysteine is degraded to oxobutanoate and H2S - Rattus norvegicus [Reaction:R-MMU-1614631] Homocysteine is degraded to oxobutanoate and H2S - Mus musculus [Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Homo sapiens [Reaction:R-SCE-1614567] Excess homocysteine yields homolanthionine and H2S - Saccharomyces cerevisiae [Reaction:R-SCE-1614567] Excess homocysteine yields homolanthionine and H2S - Saccharomyces cerevisiae [Reaction:R-SPO-1614567] Excess homocysteine yields homolanthionine and H2S - Schizosaccharomyces pombe [Reaction:R-SPO-1614567] Excess homocysteine yields homolanthionine and H2S - Schizosaccharomyces pombe [Reaction:R-DDI-1614567] Excess homocysteine yields homolanthionine and H2S - Dictyostelium discoideum [Reaction:R-DDI-1614567] Excess homocysteine yields homolanthionine and H2S - Dictyostelium discoideum [Reaction:R-CEL-1614567] Excess homocysteine yields homolanthionine and H2S - Caenorhabditis elegans [Reaction:R-CEL-1614567] Excess homocysteine yields homolanthionine and H2S - Caenorhabditis elegans [Reaction:R-DME-1614567] Excess homocysteine yields homolanthionine and H2S - Drosophila melanogaster [Reaction:R-DME-1614567] Excess homocysteine yields homolanthionine and H2S - Drosophila melanogaster [Reaction:R-GGA-1614567] Excess homocysteine yields homolanthionine and H2S - Gallus gallus [Reaction:R-GGA-1614567] Excess homocysteine yields homolanthionine and H2S - Gallus gallus [Reaction:R-XTR-1614567] Excess homocysteine yields homolanthionine and H2S - Xenopus tropicalis [Reaction:R-XTR-1614567] Excess homocysteine yields homolanthionine and H2S - Xenopus tropicalis [Reaction:R-DRE-1614567] Excess homocysteine yields homolanthionine and H2S - Danio rerio [Reaction:R-DRE-1614567] Excess homocysteine yields homolanthionine and H2S - Danio rerio [Reaction:R-SSC-1614567] Excess homocysteine yields homolanthionine and H2S - Sus scrofa [Reaction:R-SSC-1614567] Excess homocysteine yields homolanthionine and H2S - Sus scrofa [Reaction:R-BTA-1614567] Excess homocysteine yields homolanthionine and H2S - Bos taurus [Reaction:R-BTA-1614567] Excess homocysteine yields homolanthionine and H2S - Bos taurus [Reaction:R-CFA-1614567] Excess homocysteine yields homolanthionine and H2S - Canis familiaris [Reaction:R-CFA-1614567] Excess homocysteine yields homolanthionine and H2S - Canis familiaris [Reaction:R-RNO-1614567] Excess homocysteine yields homolanthionine and H2S - Rattus norvegicus [Reaction:R-RNO-1614567] Excess homocysteine yields homolanthionine and H2S - Rattus norvegicus [Reaction:R-MMU-1614567] Excess homocysteine yields homolanthionine and H2S - Mus musculus [Reaction:R-MMU-1614567] Excess homocysteine yields homolanthionine and H2S - Mus musculus [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S - Homo sapiens [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S - Homo sapiens [Reaction:R-SCE-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Saccharomyces cerevisiae [Reaction:R-DDI-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Dictyostelium discoideum [Reaction:R-CEL-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Caenorhabditis elegans [Reaction:R-DME-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Drosophila melanogaster [Reaction:R-GGA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Gallus gallus [Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Homo sapiens [Reaction:R-MMU-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Mus musculus [Reaction:R-RNO-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Rattus norvegicus [Reaction:R-CFA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Canis familiaris [Reaction:R-BTA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Bos taurus [Reaction:R-SSC-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Sus scrofa [FailedReaction:R-HSA-3322140] Defective MTR does not transfer CH3 group from MeCbl to HCYS - Homo sapiens [Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Homo sapiens [Reaction:R-MMU-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Mus musculus [Reaction:R-MMU-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Mus musculus [Reaction:R-HSA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Homo sapiens [Reaction:R-RNO-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Rattus norvegicus [Reaction:R-RNO-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Rattus norvegicus [Reaction:R-RNO-174374] MTR transfers CH3 from MeCbl to HCYS - Rattus norvegicus [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens [Reaction:R-MMU-174374] MTR transfers CH3 from MeCbl to HCYS - Mus musculus [Reaction:R-CFA-174374] MTR transfers CH3 from MeCbl to HCYS - Canis familiaris [Reaction:R-CFA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Canis familiaris [Reaction:R-CFA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Canis familiaris [Reaction:R-BTA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Bos taurus [Reaction:R-SSC-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Sus scrofa [Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS - Sus scrofa [Reaction:R-SSC-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Sus scrofa [Reaction:R-DRE-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Danio rerio [Reaction:R-DRE-174374] MTR transfers CH3 from MeCbl to HCYS - Danio rerio [Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Danio rerio [Reaction:R-GGA-174374] MTR transfers CH3 from MeCbl to HCYS - Gallus gallus [Reaction:R-GGA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Gallus gallus [Reaction:R-GGA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Gallus gallus [Reaction:R-BTA-174374] MTR transfers CH3 from MeCbl to HCYS - Bos taurus [Reaction:R-BTA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Bos taurus [Reaction:R-CEL-174374] MTR transfers CH3 from MeCbl to HCYS - Caenorhabditis elegans [Reaction:R-DDI-174374] MTR transfers CH3 from MeCbl to HCYS - Dictyostelium discoideum
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
dbId	174369
displayName	HCYS [cytosol]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9908226] D'Eustachio, Peter, 2024-04-19
name	HCYS homocysteine homocysteine zwitterion
positivelyRegulates	[PositiveRegulation:R-HSA-1655890] Positive regulation by 'HCYS [cytosol]'
producedByEvent	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens [Reaction:R-MMU-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Mus musculus [Reaction:R-RNO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Rattus norvegicus [Reaction:R-CFA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Canis familiaris [Reaction:R-BTA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Bos taurus [Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Sus scrofa [Reaction:R-DRE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Danio rerio [Reaction:R-GGA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Gallus gallus [Reaction:R-CEL-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Caenorhabditis elegans [Reaction:R-DDI-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Dictyostelium discoideum [Reaction:R-XTR-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Xenopus tropicalis [Reaction:R-DME-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Drosophila melanogaster [Reaction:R-SPO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Schizosaccharomyces pombe [Reaction:R-SCE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Saccharomyces cerevisiae [Reaction:R-SPO-379464] COMT transfers Met to DOPAC to form HVA - Schizosaccharomyces pombe [Reaction:R-GGA-379464] COMT transfers Met to DOPAC to form HVA - Gallus gallus [Reaction:R-XTR-379464] COMT transfers Met to DOPAC to form HVA - Xenopus tropicalis [Reaction:R-DRE-379464] COMT transfers Met to DOPAC to form HVA - Danio rerio [Reaction:R-SSC-379464] COMT transfers Met to DOPAC to form HVA - Sus scrofa [Reaction:R-BTA-379464] COMT transfers Met to DOPAC to form HVA - Bos taurus [Reaction:R-CFA-379464] COMT transfers Met to DOPAC to form HVA - Canis familiaris [Reaction:R-RNO-379464] COMT transfers Met to DOPAC to form HVA - Rattus norvegicus [Reaction:R-MMU-379464] COMT transfers Met to DOPAC to form HVA - Mus musculus [Reaction:R-HSA-379464] COMT transfers Met to DOPAC to form HVA - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:58199] L-homocysteine zwitterion [ChEBI:58199]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-174369
updateTrackers	[UpdateTracker:9903083] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v80:[addName, add_removeReferenceEntity] [UpdateTracker:9889935] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v52:[modifyName] [UpdateTracker:9874215] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v43:[addName]

Referrals

(input)	[FailedReaction:R-HSA-3322140] Defective MTR does not transfer CH3 group from MeCbl to HCYS [Reaction:R-SCE-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-SPO-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-DDI-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-CEL-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-DME-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-GGA-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-XTR-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-DRE-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-SSC-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-BTA-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-CFA-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-RNO-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-MMU-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-SCE-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-SPO-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-DDI-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-CEL-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-DME-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-GGA-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-XTR-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-DRE-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-SSC-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-BTA-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-CFA-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-RNO-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-MMU-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-SCE-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-DDI-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-CEL-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-DME-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-GGA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-MMU-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-MMU-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-HSA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-RNO-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-RNO-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-RNO-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-MMU-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-CFA-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-CFA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-CFA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-BTA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-SSC-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-SSC-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-DRE-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-DRE-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-GGA-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-GGA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-GGA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-BTA-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-BTA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Reaction:R-CEL-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-DDI-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-MMU-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-RNO-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-CFA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-BTA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-SSC-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
(output)	[Reaction:R-SPO-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-GGA-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-XTR-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-DRE-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-SSC-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-BTA-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-CFA-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-RNO-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-MMU-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-HSA-379464] COMT transfers Met to DOPAC to form HVA [Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-MMU-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-RNO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-CFA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-BTA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-DRE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-GGA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-CEL-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-DDI-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-XTR-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-DME-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-SPO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Reaction:R-SCE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy
(regulator)	[PositiveRegulation:R-HSA-1655890] Positive regulation by 'HCYS [cytosol]'
(updatedInstance)	[UpdateTracker:9903083] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v80:[addName, add_removeReferenceEntity] [UpdateTracker:9889935] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v52:[modifyName] [UpdateTracker:9874215] Update Tracker - [SimpleEntity:174369] HCYS [cytosol] - v43:[addName]

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