Reactome | COMT transfers Met to DOPAC to form HVA

Schema > Reaction > Entries

COMT transfers Met to DOPAC to form HVA Show undefined attributes

catalystActivity	[CatalystActivity:10580779] methyltransferase activity of COMT [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10580810
displayName	COMT transfers Met to DOPAC to form HVA
eventOf	[Pathway:R-DRE-379398] Enzymatic degradation of Dopamine by monoamine oxidase - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-379464] COMT transfers Met to DOPAC to form HVA - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-9677997] DOPAC [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	COMT transfers Met to DOPAC to form HVA Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
output	[SimpleEntity:R-ALL-174369] HCYS [cytosol] [SimpleEntity:R-ALL-9677992] HVA [cytosol]
precedingEvent	[Reaction:R-DRE-379382] MAOA:FAD deaminates DA to DOPAC - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-379464
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-379398] Enzymatic degradation of Dopamine by monoamine oxidase
(inferredTo)	[Reaction:R-HSA-379464] COMT transfers Met to DOPAC to form HVA

Cite Us!