Reactome | PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine

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PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine Show undefined attributes

catalystActivity	[CatalystActivity:11017411] cystathionine beta-synthase activity of PXLP-K119-CBS tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11017413
displayName	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
eventOf	[Pathway:R-DDI-1614603] Cysteine formation from homocysteine - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-1614583] PXLP-K212-CTH cleaves L-Cystathionine - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Homo sapiens
input	[SimpleEntity:R-ALL-174369] HCYS [cytosol] [SimpleEntity:R-ALL-200736] L-Ser [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine L-homocysteine + L-serine => H2O + L,L-cystathionine
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1614518] L-Cystathionine [cytosol]
precedingEvent	[Reaction:R-DDI-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1614524
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1614603] Cysteine formation from homocysteine
(precedingEvent)	[Reaction:R-DDI-1614583] PXLP-K212-CTH cleaves L-Cystathionine
(inferredTo)	[Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine

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