Reactome | BHMT2 tetramer transfers CH3 group from SMM to LHCYS

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BHMT2 tetramer transfers CH3 group from SMM to LHCYS Show undefined attributes

catalystActivity	[CatalystActivity:10064480] S-methylmethionine-homocysteine S-methyltransferase activity of BHMT2:Zn2+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10064482
displayName	BHMT2 tetramer transfers CH3 group from SMM to LHCYS
eventOf	[Pathway:R-MMU-1614635] Sulfur amino acid metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-174391] MAT1A multimers transfer Ado from ATP to L-Met - Mus musculus
inferredFrom	[Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Homo sapiens
input	[SimpleEntity:R-ALL-174369] HCYS [cytosol] [SimpleEntity:R-ALL-4789070] SMM [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	BHMT2 tetramer transfers CH3 group from SMM to LHCYS L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-174390] L-Met [cytosol]
precedingEvent	[Reaction:R-MMU-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5696838
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1614635] Sulfur amino acid metabolism
(inferredTo)	[Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS
(precedingEvent)	[Reaction:R-MMU-174391] MAT1A multimers transfer Ado from ATP to L-Met

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