Reactome | BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY

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BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY Show undefined attributes

authored	[InstanceEdit:1237120] Stephan, R, 2010-10-24
catalystActivity	[CatalystActivity:1614655] betaine-homocysteine S-methyltransferase activity of BHMT:Zn2+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
crossReference	[DatabaseIdentifier:12667639] RHEA:22337 [DatabaseIdentifier:9929703] RHEA:22337
dbId	1614654
displayName	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY
edited	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
eventOf	[Pathway:R-HSA-1614635] Sulfur amino acid metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6797962] DMGLY translocates from cytosol to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met - Homo sapiens
input	[SimpleEntity:R-ALL-352015] BET [cytosol] [SimpleEntity:R-ALL-174369] HCYS [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1614643] Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine Remethylation of homocysteine via betaine degradation
orthologousEvent	[Reaction:R-MMU-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Mus musculus [Reaction:R-RNO-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Rattus norvegicus [Reaction:R-BTA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Bos taurus [Reaction:R-GGA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Gallus gallus [Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Danio rerio [Reaction:R-SSC-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Sus scrofa [Reaction:R-CFA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Canis familiaris
output	[SimpleEntity:R-ALL-1614585] DMGLY [cytosol] [SimpleEntity:R-ALL-174390] L-Met [cytosol]
precedingEvent	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens [Reaction:R-HSA-6797957] SLC22A4 transports BET from mitochondrial matrix to cytosol - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1614654
summation	[Summation:1614637] Remethylation of homocysteine (HCYS) to methionine (L-Met) c...
updateTrackers	[UpdateTracker:9784034] Update Tracker - [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - v55:[modifyText] [UpdateTracker:9783472] Update Tracker - [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784034] Update Tracker - [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - v55:[modifyText] [UpdateTracker:9783472] Update Tracker - [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - v56:[modifyText]
(hasEvent)	[Pathway:R-HSA-1614635] Sulfur amino acid metabolism [Pathway:R-HSA-6798163] Choline catabolism
(precedingEvent)	[BlackBoxEvent:R-HSA-6797962] DMGLY translocates from cytosol to mitochondrial matrix [Reaction:R-HSA-174391] MAT1A multimers transfer Ado from ATP to L-Met

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