Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

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AHCY:NAD+ tetramer hydrolyses AdoHcy Show undefined attributes

catalystActivity	[CatalystActivity:11085308] adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11085310
displayName	AHCY:NAD+ tetramer hydrolyses AdoHcy
eventOf	[Pathway:R-SCE-156581] Methylation - Saccharomyces cerevisiae [Pathway:R-SCE-1614635] Sulfur amino acid metabolism - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-1614631] Homocysteine is degraded to oxobutanoate and H2S - Saccharomyces cerevisiae [Reaction:R-SCE-1614567] Excess homocysteine yields homolanthionine and H2S - Saccharomyces cerevisiae [Reaction:R-SCE-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens
input	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AHCY:NAD+ tetramer hydrolyses AdoHcy H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine
output	[SimpleEntity:R-ALL-83909] Ade-Rib [cytosol] [SimpleEntity:R-ALL-174369] HCYS [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-174401
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-156581] Methylation [Pathway:R-SCE-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-SCE-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-SCE-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-SCE-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
(inferredTo)	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy