Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

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AHCY:NAD+ tetramer hydrolyses AdoHcy Show undefined attributes

catalystActivity	[CatalystActivity:10571746] adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10571748
displayName	AHCY:NAD+ tetramer hydrolyses AdoHcy
eventOf	[Pathway:R-DRE-1614635] Sulfur amino acid metabolism - Danio rerio [Pathway:R-DRE-156581] Methylation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1614631] Homocysteine is degraded to oxobutanoate and H2S - Danio rerio [Reaction:R-DRE-1614567] Excess homocysteine yields homolanthionine and H2S - Danio rerio [Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Danio rerio [Reaction:R-DRE-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Danio rerio [Reaction:R-DRE-174374] MTR transfers CH3 from MeCbl to HCYS - Danio rerio
inferredFrom	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Homo sapiens
input	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AHCY:NAD+ tetramer hydrolyses AdoHcy H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine
output	[SimpleEntity:R-ALL-83909] Ade-Rib [cytosol] [SimpleEntity:R-ALL-174369] HCYS [cytosol]
precedingEvent	[Reaction:R-DRE-158609] TPMT transfers CH3 from AdoMet to 6MP - Danio rerio [Reaction:R-DRE-175987] NNMT transfers CH3 from AdoMet to PY - Danio rerio [Reaction:R-DRE-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-174401
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-156581] Methylation [Pathway:R-DRE-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-DRE-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-DRE-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-DRE-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-DRE-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-DRE-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS
(inferredTo)	[Reaction:R-HSA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy