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Schema
>
FailedReaction
>
Entries
Defective MTR does not transfer CH3 group from MeCbl to HCYS
Show undefined attributes
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authored
[InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
crossReference
[DatabaseIdentifier:12020852] Mondo:0009609
dbId
3322140
disease
[Disease:3322121] methylmalonic aciduria and homocystinuria type cblG
displayName
Defective MTR does not transfer CH3 group from MeCbl to HCYS
edited
[InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
entityFunctionalStatus
[EntityFunctionalStatus:9013302] loss_of_function of MTRR:mutant MTR(MeCbl) [cytosol]
eventOf
[Pathway:R-HSA-3359469] Defective MTR causes HMAG - Homo sapiens
input
[SimpleEntity:R-ALL-174369] HCYS [cytosol]
[Complex:R-HSA-9013305] MTRR:mutant MTR(MeCbl) [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:200732] Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
[LiteratureReference:3321915] Defects in human methionine synthase in cblG patients
[LiteratureReference:3322111] Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Defective MTR does not transfer CH3 group from MeCbl to HCYS
normalReaction
[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS
releaseDate
2013-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4093346] Watkins, D, 2013-08-14
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3322140
summation
[Summation:3322134] Methionine synthase (MTR) catalyses the transfer of a methyl...
updateTrackers
[UpdateTracker:9780668] Update Tracker - [FailedReaction:3322140] Defective MTR does not transfer CH3 group from MeCbl to HCYS - v62:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9780668] Update Tracker - [FailedReaction:3322140] Defective MTR does not transfer CH3 group from MeCbl to HCYS - v62:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-3359469] Defective MTR causes HMAG
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