Reactome | MTR transfers CH3 from MeCbl to HCYS

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MTR transfers CH3 from MeCbl to HCYS Show undefined attributes

catalystActivity	[CatalystActivity:11004793] methionine synthase activity of MTRR:MTR:MeCbl [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11004795
displayName	MTR transfers CH3 from MeCbl to HCYS
eventOf	[Pathway:R-DDI-1614635] Sulfur amino acid metabolism - Dictyostelium discoideum [Pathway:R-DDI-156581] Methylation - Dictyostelium discoideum [Pathway:R-DDI-9759218] Cobalamin (Cbl) metabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-174391] MAT1A multimers transfer Ado from ATP to L-Met - Dictyostelium discoideum [Reaction:R-DDI-3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens
input	[SimpleEntity:R-ALL-174369] HCYS [cytosol] [Complex:R-DDI-3149551] MTRR:MTR:MeCbl [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTR transfers CH3 from MeCbl to HCYS Methionine is reformed
output	[SimpleEntity:R-ALL-174390] L-Met [cytosol] [Complex:R-DDI-3149516] MTRR:MTR:cob(I)alamin [cytosol]
precedingEvent	[Reaction:R-DDI-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Dictyostelium discoideum [Reaction:R-DDI-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Dictyostelium discoideum [Reaction:R-DDI-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Dictyostelium discoideum [Reaction:R-DDI-3149518] MTRR reduces cob(II)alamin to meCbl - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-174374
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9759218] Cobalamin (Cbl) metabolism [Pathway:R-DDI-156581] Methylation [Pathway:R-DDI-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-DDI-174391] MAT1A multimers transfer Ado from ATP to L-Met [Reaction:R-DDI-3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
(inferredTo)	[Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS