Reactome | Homocysteine is degraded to oxobutanoate and H2S

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Homocysteine is degraded to oxobutanoate and H2S Show undefined attributes

catalystActivity	[CatalystActivity:10773679] homocysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10773681
displayName	Homocysteine is degraded to oxobutanoate and H2S
eventOf	[Pathway:R-GGA-1614558] Degradation of cysteine and homocysteine - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-174369] HCYS [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Homocysteine is degraded to oxobutanoate and H2S H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)
output	[SimpleEntity:R-ALL-936714] 2OBUTA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1614532] H2S [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-GGA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1614631
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1614558] Degradation of cysteine and homocysteine
(inferredTo)	[Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S

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