Reactome | Excess homocysteine yields homolanthionine and H2S

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Excess homocysteine yields homolanthionine and H2S Show undefined attributes

catalystActivity	[CatalystActivity:10950995] carbon-sulfur lyase activity of PXLP-K212-CTH tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10950997
displayName	Excess homocysteine yields homolanthionine and H2S
eventOf	[Pathway:R-CEL-1614558] Degradation of cysteine and homocysteine - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S - Homo sapiens
input	2 × [SimpleEntity:R-ALL-174369] HCYS [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Excess homocysteine yields homolanthionine and H2S 2 L-homocysteine => L-homolanthionine + hydrogen sulfide + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1614532] H2S [cytosol] [SimpleEntity:R-ALL-1614594] HLAN [cytosol]
precedingEvent	[Reaction:R-CEL-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Caenorhabditis elegans
regulatedBy	[PositiveRegulation:R-HSA-1655890] Positive regulation by 'HCYS [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1614567
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1614558] Degradation of cysteine and homocysteine
(inferredTo)	[Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S

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