Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

Schema > Reaction > Entries

AHCY:NAD+ tetramer hydrolyses AdoHcy Show undefined attributes

catalystActivity	[CatalystActivity:174397] adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:12667632] RHEA:21709 [DatabaseIdentifier:9929682] RHEA:21709
dbId	174401
diseaseReaction	[FailedReaction:R-HSA-5579084] Defective AHCY does not hydrolyse AdoHcy - Homo sapiens
displayName	AHCY:NAD+ tetramer hydrolyses AdoHcy
eventOf	[Pathway:R-HSA-1614635] Sulfur amino acid metabolism - Homo sapiens [Pathway:R-HSA-156581] Methylation - Homo sapiens
followingEvent	[Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Homo sapiens [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S - Homo sapiens [Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - Homo sapiens [Reaction:R-HSA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY - Homo sapiens [Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS - Homo sapiens [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS - Homo sapiens
input	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5579074] Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength [LiteratureReference:5579036] Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	AHCY:NAD+ tetramer hydrolyses AdoHcy H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine
orthologousEvent	[Reaction:R-SCE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Saccharomyces cerevisiae [Reaction:R-SPO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Schizosaccharomyces pombe [Reaction:R-DME-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Drosophila melanogaster [Reaction:R-XTR-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Xenopus tropicalis [Reaction:R-MMU-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Mus musculus [Reaction:R-RNO-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Rattus norvegicus [Reaction:R-DDI-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Dictyostelium discoideum [Reaction:R-CEL-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Caenorhabditis elegans [Reaction:R-CFA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Canis familiaris [Reaction:R-BTA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Bos taurus [Reaction:R-GGA-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Gallus gallus [Reaction:R-DRE-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Danio rerio [Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Sus scrofa
output	[SimpleEntity:R-ALL-83909] Ade-Rib [cytosol] [SimpleEntity:R-ALL-174369] HCYS [cytosol]
precedingEvent	[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens [Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME - Homo sapiens [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY - Homo sapiens [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174401
summation	[Summation:179165] Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, c...
systematicName	AHCY:NAD+ tetramer hydrolyses AdoHcy, H2O to HCYS, Ade-Rib
updateTrackers	[UpdateTracker:9786102] Update Tracker - [Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - v50:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786102] Update Tracker - [Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - v50:[addLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-5579084] Defective AHCY does not hydrolyse AdoHcy
(hasEvent)	[Pathway:R-HSA-156581] Methylation [Pathway:R-HSA-1614635] Sulfur amino acid metabolism
(precedingEvent)	[Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S [Reaction:R-HSA-1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Reaction:R-HSA-174374] MTR transfers CH3 from MeCbl to HCYS [Reaction:R-HSA-1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Reaction:R-HSA-5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS

Cite Us!