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Schema
>
LiteratureReference
>
Entries
Mutations of the BRAF gene in human cancer
Show undefined attributes
author
[Person:1614051] Davies, H
[Person:5672208] Bignell, GR
[Person:5672216] Cox, C
[Person:5672225] Stephens, P
[Person:1614058] Edkins, S
[Person:5672234] Clegg, S
[Person:1614185] Teague, J
[Person:5672237] Woffendin, H
[Person:3004690] Garnett, MJ
[Person:5672211] Bottomley, W
[Person:5672214] Davis, N
[Person:1614052] Dicks, E
[Person:5672231] Ewing, R
[Person:5672210] Floyd, Y
[Person:1614078] Gray, K
[Person:5672222] Hall, S
[Person:5672226] Hawes, R
[Person:5672239] Hughes, J
[Person:5672227] Kosmidou, V
[Person:1614132] Menzies, A
[Person:5672221] Mould, C
[Person:1614262] Parker, A
[Person:1614174] Stevens, C
[Person:5672219] Watt, S
[Person:5672230] Hooper, S
[Person:5672220] Wilson, R
[Person:5672232] Jayatilake, H
[Person:5672218] Gusterson, BA
[Person:1834970] Cooper, C
[Person:1834971] Shipley, J
[Person:5672229] Hargrave, D
[Person:5672235] Pritchard-Jones, K
[Person:5672233] Maitland, N
[Person:2018730] Chenevix-Trench, G
[Person:881876] Riggins, GJ
[Person:5658259] Bigner, DD
[Person:5672213] Palmieri, G
[Person:5672209] Cossu, A
[Person:2730996] Flanagan, A
[Person:5672224] Nicholson, A
[Person:5672223] Ho, JW
[Person:1614115] Leung, SY
[Person:1614211] Yuen, ST
[Person:5672238] Weber, BL
[Person:5672228] Seigler, HF
[Person:5672215] Darrow, TL
[Person:5672212] Paterson, H
[Person:1497943] Marais, R
[Person:5663093] Marshall, CJ
[Person:1614207] Wooster, R
[Person:1614179] Stratton, MR
[Person:3318334] Futreal, PA
created
[InstanceEdit:5672217] Rothfels, Karen, 2015-02-04
dbId
5672236
displayName
Mutations of the BRAF gene in human cancer
journal
Nature
pages
949-54
pubMedIdentifier
12068308
schemaClass
LiteratureReference
title
Mutations of the BRAF gene in human cancer
url
http://www.ncbi.nlm.nih.gov/pubmed/12068308
volume
417
year
2002
Referrals
(author)
[Person:5672233] Maitland, N
[Person:5672232] Jayatilake, H
[Person:3318334] Futreal, PA
[Person:1614211] Yuen, ST
[Person:5663093] Marshall, CJ
[Person:1614132] Menzies, A
[Person:1614262] Parker, A
[Person:2018730] Chenevix-Trench, G
[Person:1614115] Leung, SY
[Person:3004690] Garnett, MJ
[Person:5672214] Davis, N
[Person:1834971] Shipley, J
[Person:1834970] Cooper, C
[Person:5672215] Darrow, TL
[Person:1497943] Marais, R
[Person:5672212] Paterson, H
[Person:5672213] Palmieri, G
[Person:5672210] Floyd, Y
[Person:5672211] Bottomley, W
[Person:5658259] Bigner, DD
[Person:5672208] Bignell, GR
[Person:1614174] Stevens, C
[Person:5672209] Cossu, A
[Person:5672222] Hall, S
[Person:5672223] Ho, JW
[Person:5672220] Wilson, R
[Person:5672221] Mould, C
[Person:5672218] Gusterson, BA
[Person:5672219] Watt, S
[Person:5672216] Cox, C
[Person:881876] Riggins, GJ
[Person:2730996] Flanagan, A
[Person:1614078] Gray, K
[Person:1614207] Wooster, R
[Person:5672230] Hooper, S
[Person:1614185] Teague, J
[Person:5672231] Ewing, R
[Person:1614058] Edkins, S
[Person:5672228] Seigler, HF
[Person:5672229] Hargrave, D
[Person:5672226] Hawes, R
[Person:5672227] Kosmidou, V
[Person:5672224] Nicholson, A
[Person:5672225] Stephens, P
[Person:5672238] Weber, BL
[Person:5672239] Hughes, J
[Person:1614051] Davies, H
[Person:5672237] Woffendin, H
[Person:1614179] Stratton, MR
[Person:5672234] Clegg, S
[Person:1614052] Dicks, E
[Person:5672235] Pritchard-Jones, K
(literatureReference)
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
[DefinedSet:R-HSA-6802629] kinase dead BRAF mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802299] BRAF D594N [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802385] BRAF G596R [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802305] BRAF D594V [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802374] BRAF G466E [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802295] BRAF D594G [cytosol]
[Reaction:R-HSA-8936676] Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP
[CandidateSet:R-HSA-6802641] moderate kinase activity BRAF mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802316] BRAF F595L [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802397] BRAF L597V [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802369] BRAF G464E [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802308] BRAF E586K [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802502] BRAF V600K [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648621] BRAF G469R [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648618] BRAF G469E [cytosol]
[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8936647] p-BRAF L597V [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8936645] p-BRAF G464E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8936641] p-BRAF F595L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8936639] p-BRAF E586K [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8936651] p-BRAF V600K [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9648634] p-BRAF G469E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9648627] p-BRAF G469R [plasma membrane]
[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants
[Reaction:R-HSA-6802910] Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
[Reaction:R-HSA-6802911] High kinase activity BRAF complexes phosphorylate MAP2Ks
[EntityWithAccessionedSequence:R-HSA-6802381] BRAF G469A [cytosol]
[EntityWithAccessionedSequence:R-HSA-6802498] BRAF V600E [cytosol]
[Pathway:R-HSA-5673000] RAF activation
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