Reactome | Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize

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Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8936677] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	8936676
disease	[Disease:1500689] cancer
displayName	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:8936673] gain_of_function of p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane]
eventOf	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
input	[DefinedSet:R-HSA-8936661] 'receiver' RAF [cytosol] [Complex:R-HSA-8936669] p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
normalReaction	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
output	[Complex:R-HSA-6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
precedingEvent	[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8936737] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]' [PositiveRegulation:R-HSA-8936746] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8936676
summation	[Summation:6802210] In addition to the prevalent and highly activating V600E mut...

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(hasEvent)

[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants

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