Reactome | p-BRAF E586K [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8936638] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:6802310] COSMIC:COSV56082407
dbId	8936639
disease	[Disease:1500575] ovarian cancer [Disease:1614289] melanoma
displayName	p-BRAF E586K [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802309] L-glutamic acid 586 replaced with L-lysine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
memberOf	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9651202] Rothfels, Karen, 2019-06-25
name	p-BRAF E586K B-RAF
referenceEntity	[ReferenceGeneProduct:58251] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-8936639
startCoordinate	2

(hasMember)

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