Reactome | p-BRAF V600K [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8936650] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105 [DatabaseIdentifier:6802500] COSMIC:COSV56057713
dbId	8936651
disease	[Disease:1614289] melanoma
displayName	p-BRAF V600K [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802503] L-valine 600 replaced with L-lysine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
maxDepth	1
memberOf	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646281] Rothfels, Karen, 2019-05-21
name	p-BRAF V600K B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-8936651
startCoordinate	2
updateTrackers	[UpdateTracker:9900733] Update Tracker - [EntityWithAccessionedSequence:8936651] p-BRAF V600K [plasma membrane] - v70:[modifyName]

(updatedInstance)	[UpdateTracker:9900733] Update Tracker - [EntityWithAccessionedSequence:8936651] p-BRAF V600K [plasma membrane] - v70:[modifyName]
(hasMember)	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane]

Cite Us!