Reactome | phosphorylated moderate kinase activity BRAF mutants [plasma membrane]

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phosphorylated moderate kinase activity BRAF mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-8936663] phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane] - Homo sapiens
created	[InstanceEdit:8936657] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:12020780] Mondo:0015280
dbId	8936658
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
displayName	phosphorylated moderate kinase activity BRAF mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9648633] p-BRAF G464V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648629] p-BRAF G466A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648859] p-BRAF G466V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648634] p-BRAF G469E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648627] p-BRAF G469R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648628] p-BRAF G469V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648630] p-BRAF L597Q [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648631] p-BRAF L597R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648866] p-BRAF N581S [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651194] p-BRAF T244P [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-8936639] p-BRAF E586K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8936641] p-BRAF F595L [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8936645] p-BRAF G464E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8936647] p-BRAF L597V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8936651] p-BRAF V600K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648862] p-BRAF L505H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651191] p-BRAF N581D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651188] p-BRAF A246P [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:9651037] Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome
maxDepth	2
modified	[InstanceEdit:9657036] Rothfels, Karen, 2019-08-06
name	phosphorylated moderate kinase activity BRAF mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-8936658

Referrals

(hasComponent)

[Complex:R-HSA-8936663] phosphorylated moderate kinase activity BRAF mutants:YWHAB [plasma membrane]

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