Reactome | BRAF G469A [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802382] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020755] Mondo:0008903 [DatabaseIdentifier:6802379] COSMIC:COSV56061424 [DatabaseIdentifier:6802380] COSMIC:COSM29608
dbId	6802381
disease	[Disease:1500699] lung cancer
displayName	BRAF G469A [cytosol]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802378] glycine 469 replaced with L-alanine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
maxDepth	1
memberOf	[DefinedSet:R-HSA-6802579] high kinase activity BRAF mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9648699] Rothfels, Karen, 2019-06-07
name	BRAF G469A B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802381
startCoordinate	2
updateTrackers	[UpdateTracker:9900618] Update Tracker - [EntityWithAccessionedSequence:6802381] BRAF G469A [cytosol] - v70:[addHasModifiedResidue, modifyName]

(updatedInstance)	[UpdateTracker:9900618] Update Tracker - [EntityWithAccessionedSequence:6802381] BRAF G469A [cytosol] - v70:[addHasModifiedResidue, modifyName]
(hasMember)	[DefinedSet:R-HSA-6802579] high kinase activity BRAF mutants [cytosol]

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