Reactome | p-BRAF G464E [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8936644] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:6802372] COSMIC:COSV56075378 [DatabaseIdentifier:6802371] COSMIC:COSM36376
dbId	8936645
disease	[Disease:1614289] melanoma
displayName	p-BRAF G464E [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802370] glycine 464 replaced with L-glutamic acid [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
memberOf	[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646281] Rothfels, Karen, 2019-05-21
name	p-BRAF G464E B-RAF
referenceEntity	[ReferenceGeneProduct:58251] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-8936645
startCoordinate	2

(hasMember)

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