Reactome | BRAF G466E [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802377] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105 [DatabaseIdentifier:6802375] COSMIC:COSV56059390
dbId	6802374
disease	[Disease:1614289] melanoma
displayName	BRAF G466E [cytosol]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802376] glycine 466 replaced with L-glutamic acid
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
maxDepth	1
memberOf	[DefinedSet:R-HSA-6802629] kinase dead BRAF mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9646281] Rothfels, Karen, 2019-05-21
name	BRAF G466E B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802374
startCoordinate	2
updateTrackers	[UpdateTracker:9900653] Update Tracker - [EntityWithAccessionedSequence:6802374] BRAF G466E [cytosol] - v70:[modifyName]

(updatedInstance)	[UpdateTracker:9900653] Update Tracker - [EntityWithAccessionedSequence:6802374] BRAF G466E [cytosol] - v70:[modifyName]
(hasMember)	[DefinedSet:R-HSA-6802629] kinase dead BRAF mutants [cytosol]

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