Reactome | p-BRAF G469E [plasma membrane]

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p-BRAF G469E [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9648632] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:9648592] COSMIC:COSV56065622
dbId	9648634
disease	[Disease:1614289] melanoma [Disease:4791250] colorectal cancer [Disease:9651116] Costello syndrome [Disease:9651119] cardiofaciocutaneous syndrome
displayName	p-BRAF G469E [plasma membrane]
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:9648607] glycine 469 replaced with L-glutamine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:9646947] Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma [LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:9651037] Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome [LiteratureReference:9651055] Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome
modified	[InstanceEdit:9651204] Rothfels, Karen, 2019-06-25
name	p-BRAF G469E B-RAF
referenceEntity	[ReferenceGeneProduct:58251] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648634
startCoordinate	2

Referrals

(hasCandidate)

[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane]

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