Reactome | moderate kinase activity BRAF mutants [cytosol]

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moderate kinase activity BRAF mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-8936655] moderate kinase activity BRAF mutants:YWHAB [cytosol] - Homo sapiens [Complex:R-HSA-8936669] p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
created	[InstanceEdit:6802640] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020780] Mondo:0015280
dbId	6802641
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
displayName	moderate kinase activity BRAF mutants [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9648611] BRAF G464V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648613] BRAF G466A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648838] BRAF G466V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648618] BRAF G469E [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648621] BRAF G469R [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648620] BRAF G469V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648619] BRAF L597Q [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648617] BRAF L597R [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648850] BRAF N581S [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651165] BRAF T244P [cytosol] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-6802308] BRAF E586K [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802316] BRAF F595L [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802369] BRAF G464E [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802397] BRAF L597V [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802502] BRAF V600K [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648845] BRAF L505H [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651152] BRAF N581D [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651123] BRAF A246P [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:9651037] Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome
maxDepth	2
modified	[InstanceEdit:9656802] Rothfels, Karen, 2019-08-02
name	moderate kinase activity BRAF mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-6802641

Referrals

(hasComponent)	[Complex:R-HSA-8936669] p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane] [Complex:R-HSA-8936655] moderate kinase activity BRAF mutants:YWHAB [cytosol] [Complex:R-HSA-6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane] [Complex:R-HSA-6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
(input)	[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP
(diseaseEntity)	[EntityFunctionalStatus:6802888] gain_of_function of moderate kinase activity BRAF mutants [cytosol]

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