TRAF6:hp-IRAK1 [plasma membrane]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
The listed studies describe an activation of IRAK-TRAF6-TAK1 axes downstream of IL1 receptor signaling cascade, which is mediated by its cytosolic domain called Toll/IL1R (TIR) domain. TLRs and IL1R are thought to share a similar downstream signaling pathway due to a high homology of their C-terminal TIR domains.
Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
12242293 Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

Jiang, Z, Ninomiya-Tsuji, J, Li, X, Matsumoto, K, Qian, Y

Mol Cell Biol 2002
11518704 IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

Li, X, Matsumoto, K, Qian, Y, Commane, M, Ninomiya-Tsuji, J

J. Biol. Chem. 2001
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