The listed studies describe an activation of IRAK-TRAF6-TAK1 axes downstream of IL1 receptor signaling cascade, which is mediated by its cytosolic domain called Toll/IL1R (TIR) domain. TLRs and IL1R are thought to share a similar downstream signaling pathway due to a high homology of their C-terminal TIR domains.
Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C
Jiang, Z, Ninomiya-Tsuji, J, Li, X, Matsumoto, K, Qian, Y
Li, X, Matsumoto, K, Qian, Y, Commane, M, Ninomiya-Tsuji, J
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