Reactome | TRAF6:hp-IRAK1 [plasma membrane]

TRAF6:hp-IRAK1

Stable Identifier

R-HSA-937036

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Summation

The listed studies describe an activation of IRAK-TRAF6-TAK1 axes downstream of IL1 receptor signaling cascade, which is mediated by its cytosolic domain called Toll/IL1R (TIR) domain. TLRs and IL1R are thought to share a similar downstream signaling pathway due to a high homology of their C-terminal TIR domains.

Literature References

PubMed ID	Title	Journal	Year
12242293	Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Jiang, Z, Ninomiya-Tsuji, J, Qian, Y, Matsumoto, K, Li, X	Mol Cell Biol	2002
14625308	Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU	J Biol Chem	2004
11518704	IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B Qian, Y, Commane, M, Ninomiya-Tsuji, J, Matsumoto, K, Li, X	J. Biol. Chem.	2001