TRAF6:hp-IRAK1

Stable Identifier
R-HSA-937036
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The listed studies describe an activation of IRAK-TRAF6-TAK1 axes downstream of IL1 receptor signaling cascade, which is mediated by its cytosolic domain called Toll/IL1R (TIR) domain. TLRs and IL1R are thought to share a similar downstream signaling pathway due to a high homology of their C-terminal TIR domains.

Participants
Participant Of
Inferred To