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p-S477,S479-IRF7
Stable Identifier
R-HSA-450318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S477,479-IRF7
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)
IRF3-P:IRF7-P [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)
IRF3-P:IRF7-P [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Dimerization of p-IRF7 (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Dimerization of p-IRF7 (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Dimerization of p-IRF7 (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
p-S477,S479-IRF7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92985 IRF7
Gene Names
IRF7
Chain
chain:1-503
Reference Genes
BioGPS Gene:3665 IRF7
COSMIC (genes):IRF7 IRF7
CTD Gene:3665 IRF7
dbSNP Gene:3665 IRF7
ENSEMBL:ENSG00000185507 IRF7
ENSEMBL:ENSG00000276561 IRF7
HGNC:6122 IRF7
KEGG Gene (Homo sapiens):hsa:3665 IRF7
Monarch:3665 IRF7
NCBI Gene:3665 IRF7
OMIM:605047 IRF7
UCSC:Q92985 IRF7
Reference Transcript
RefSeq:NM_001572.3 IRF7
RefSeq:XM_005252906.3 IRF7
RefSeq:NM_004031.2 IRF7
RefSeq:XM_017017674.1 IRF7
RefSeq:NM_004029.2 IRF7
Other Identifiers
0007040541
11718916_a_at
16733995
17694
208436_s_at
2O61
3358175
3358176
3358178
3358180
3358181
3358182
3358183
3358184
3358185
3358187
3358188
3358190
3358191
3358192
3358194
3358195
3358196
3358197
3358198
3358199
3358200
36412_s_at
3665
43350_f_at
52757
74528_s_at
7945462
A0A024RCA2
A_24_P378019
AAB17190
AAB80686
AAB80688
AAB80690
AAB80691
AAC70999
AAI36556
AF076494
BC136555
CAB017694
CCDS7703
CCDS7704
CCDS7705
CH471158
EAX02355
EAX02358
EAX02359
EAX02360
ENSG00000185507
ENSG00000276561
ENSP00000329411
ENSP00000331803
ENSP00000380697
ENSP00000380704
ENSP00000433903
ENSP00000434607
ENSP00000479615
ENSP00000480358
ENSP00000488039
ENSP00000488581
ENSP00000488591
ENSP00000488666
ENST00000330243
ENST00000348655
ENST00000397566
ENST00000397574
ENST00000469048
ENST00000533182
ENST00000612534
ENST00000621391
ENST00000632827
ENST00000633274
ENST00000633943
ENST00000634105
EntrezGene:3665
g4809285_3p_s_at
GE54698
GO:0000122
GO:0000975
GO:0000979
GO:0000982
GO:0002376
GO:0002819
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006974
GO:0009615
GO:0010008
GO:0016032
GO:0016064
GO:0019043
GO:0032479
GO:0032481
GO:0032607
GO:0032608
GO:0032727
GO:0032728
GO:0034124
GO:0034127
GO:0035666
GO:0039530
GO:0045087
GO:0045351
GO:0045655
GO:0045893
GO:0045944
GO:0050776
GO:0051607
GO:0060333
GO:0060337
GO:0060340
GO:2000110
HGNC:6122
HPA052757
Hs.166120
ILMN_1674646
ILMN_1798181
ILMN_2349061
IPR001346
IPR008984
IPR011991
IPR017855
IPR019471
IPR019817
IRF7
IRF7-201
IRF7-202
IRF7-203
IRF7-205
IRF7-206
IRF7-215
IRF7-217
IRF7-219
IRF7-225
IRF7-228
IRF7-231
IRF7-232
M9RSF4
MIM:605047
MIM:616345
NM_001572
NM_004029
NM_004031
NP_001563
NP_004020
NP_004022
PF00605
PF10401
PH_hs_0010006
PR00267
SM00348
SM01243
TC11001241.hg
U53830
U53830_at
U53831
U53832
U73036
uc001lqg.3
uc001lqh.4
uc057xin.1
uc057xio.1
uc057xiq.1
uc057xis.1
UPI000002AC07
UPI000013C5D4
UPI000013C689
UPI000013FC1C
XM_005252906
XM_005252907
XM_011520066
XP_005252963
XP_005252964
XP_011518368
Participant Of
input
Dimerization of p-IRF7
hasMember
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol]
hasComponent
IRF3-P:IRF7-P [cytosol]
p-2S-IRF7:p-2S-IRF7 [cytosol]
output
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
Phosphorylation and release of IRF7
Other forms of this molecule
K63polyUb-IRF7 [endosome membrane]
IRF7 [cytosol]
IRF7 [endosome membrane]
p-S477,S479-IRF7 [nucleoplasm]
Inferred To
Homologues of p-S477,S479-IRF7 [cytosol] (Danio rerio)
Homologues of p-S477,S479-IRF7 [cytosol] (Sus scrofa)
phospho-p-S477,S479-IRF7 [cytosol] (Bos taurus)
phospho-p-S477,S479-IRF7 [cytosol] (Canis familiaris)
phospho-p-S477,S479-IRF7 [cytosol] (Danio rerio)
phospho-p-S477,S479-IRF7 [cytosol] (Gallus gallus)
phospho-p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-p-S477,S479-IRF7 [cytosol] (Rattus norvegicus)
phospho-p-S477,S479-IRF7 [cytosol] (Sus scrofa)
phospho-p-S477,S479-IRF7 [cytosol] (Taeniopygia guttata)
phospho-p-S477,S479-IRF7 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 477
Coordinate
477
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 479
Coordinate
479
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005252963.1
,
NP_001563.2
,
XP_016873163.1
,
NP_004020.1
,
NP_004022.2
GeneCards
Q92985
DOCK Blaster
2O61
PRO
Q92985
Orphanet
24630
PDB
2O61
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29128 ICP0
0.556
5
UniProt:Q9UHD2 TBK1
6
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
p-S172-TBK1 [plasma membrane]
(R-HSA-936983)
p-S172-TBK1 [endosome membrane]
(R-HSA-450290)
TBK1 [cytosol]
(R-HSA-166267)
0.508
2
UniProt:F5HDE4 ORF45
0.508
3
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.499
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.499
2
UniProt:Q9BVS5 TRMT61B
1
TRMT61B [mitochondrial matrix]
(R-HSA-6787512)
0.499
2
UniProt:Q86UE8 TLK2
0.499
2
UniProt:Q9ULE6 PALD
0.499
2
UniProt:Q96A33 CCD47
0.499
2
UniProt:P51617 IRAK1
14
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
IRAK1 [plasma membrane]
(R-HSA-937045)
IRAK1 [cytosol]
(R-HSA-446639)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
0.499
2
UniProt:O00170 AIP
2
AIP [cytosol]
(R-HSA-8936839)
AIP [nucleoplasm]
(R-HSA-8937156)
0.499
2
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