Reactome | p-S477,S479-IRF7 [cytosol]

p-S477,S479-IRF7 [cytosol]

Stable Identifier

R-HSA-450318

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S477,479-IRF7

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
        
        phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
        
        p-2S-IRF7:p-2S-IRF7 [cytosol] (Homo sapiens)
        
        p-S477,S479-IRF7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92985 IRF7

Gene Names

IRF7

Chain

chain:1-503

Reference Genes

BioGPS Gene:3665 IRF7

COSMIC (genes):IRF7 IRF7

CTD Gene:3665 IRF7

dbSNP Gene:3665 IRF7

ENSEMBL:ENSG00000185507 IRF7

ENSEMBL_homo_sapiens_GENE:ENSG00000185507.21 IRF7

ENSEMBL_homo_sapiens_GENE:ENSG00000276561.4 IRF7

HGNC:6122 IRF7

KEGG Gene (Homo sapiens):3665 IRF7

Monarch:3665 IRF7

NCBI Gene:3665 IRF7

OMIM:605047 IRF7

UCSC:Q92985 IRF7

Reference Transcript

Other Identifiers

11718916_a_at

16733995

208436_PM_s_at

208436_s_at

3358173

3358175

3358176

3358178

3358180

3358181

3358182

3358183

3358184

3358185

3358187

3358188

3358190

3358191

3358192

3358194

3358195

3358196

3358197

3358198

3358199

3358200

36412_s_at

3665

43350_f_at

74528_s_at

7945462

A_24_P378019

GE54698

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0000987

GO:0002376

GO:0002753

GO:0002819

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005768

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0009615

GO:0010008

GO:0010468

GO:0012501

GO:0016064

GO:0019043

GO:0023052

GO:0030154

GO:0031410

GO:0032479

GO:0032481

GO:0032727

GO:0032728

GO:0034124

GO:0034127

GO:0039530

GO:0043226

GO:0045087

GO:0045655

GO:0045893

GO:0045944

GO:0048856

GO:0050776

GO:0051607

GO:0060337

GO:0060340

GO:0098542

GO:0140110

GO:1990837

GO:2000110

HMNXSV003008948

ILMN_1674646

ILMN_1798181

ILMN_2349061

PH_hs_0010006

TC11001241.hg

U53830_at

g4809285_3p_s_at

Participates

as an output of

as an input of

Dimerization of p-IRF7 (Homo sapiens)

as a member of

p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

K63polyUb-IRF7 [endosome membrane]

IRF7 [endosome membrane]

p-S477,S479-IRF7 [nucleoplasm]

IRF7 [cytosol]

Inferred To

phospho-IRF-3 [cytosol] (Gallus gallus)

phospho-Irf7 [cytosol] (Mus musculus)

phospho-Irf7 [cytosol] (Rattus norvegicus)

phospho-IRF7 [cytosol] (Bos taurus)

phospho-IRF7 [cytosol] (Sus scrofa)

phospho-irf7 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 477

Coordinate

477

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 479

Coordinate

479

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016873163.1, NP_001563.2, NP_004020.1, XP_005252963.1, NP_004022.2

OpenTargets

ENSG00000185507

GeneCards

Q92985

HPA

ENSG00000185507-IRF7

Ensembl

ENST00000469048, ENSP00000480358, ENSP00000329411, ENST00000633943, ENST00000533182, ENST00000330243, ENST00000397566, ENSP00000380697, ENSP00000488039, ENST00000634105, ENST00000632827, ENST00000612534, ENST00000348655, ENSP00000433903, ENSP00000331803, ENSP00000479615, ENST00000633274, ENST00000525445, ENSG00000185507, ENSP00000488591, ENSG00000276561, ENSP00000488666, ENSP00000434009, ENSP00000434607, ENSP00000488581, ENST00000621391

PRO

Q92985

Pharos - Targets

Q92985

Orphanet

24630

HMDB Protein

HMDBP13795

PDB

2O61

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.623	3
UniProt:P29128 ICP0			0.556	5
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.508	2
UniProt:F5HDE4 ORF45			0.508	3
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.499	2
UniProt:Q86UE8 TLK2			0.499	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.499	2
UniProt:Q9ULE6 PALD			0.499	2
UniProt:Q96A33 CCD47			0.499	2
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.499	2
UniProt:O00170 AIP	2	AIP [cytosol] (R-HSA-8936839) AIP [nucleoplasm] (R-HSA-8937156)	0.499	2

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