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CCT6B [cytosol]
Stable Identifier
R-HSA-5216201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit zeta-2, TCPW_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
PDCL promotes G-protein beta 5 folding (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
CCT/TRiC:ADP:actin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92526 CCT6B
Gene Names
CCT6B
Chain
chain:1-530
Reference Genes
BioGPS Gene:10693 CCT6B
COSMIC (genes):CCT6B CCT6B
CTD Gene:10693 CCT6B
dbSNP Gene:10693 CCT6B
ENSEMBL:ENSG00000132141 CCT6B
HGNC:1621 CCT6B
KEGG:hsa:10693 CCT6B
Monarch:10693 CCT6B
NCBI Gene:10693 CCT6B
OMIM:610730 CCT6B
UCSC:Q92526 CCT6B
Reference Transcript
RefSeq:NM_001193530.1 CCT6B
RefSeq:NM_001193529.2 CCT6B
RefSeq:NM_006584.3 CCT6B
Other Identifiers
10693
11745585_a_at
16843323
206587_PM_at
206587_at
3753319
3753320
3753321
3753322
3753323
3753324
3753325
3753328
3753329
3753330
3753331
3753332
3753333
3753334
3753335
3753336
3753337
3753342
3753343
3753354
3753355
40361_at
8014172
A_23_P4082
D78333_at
GE57297
GO:0003824
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005832
GO:0006457
GO:0016787
GO:0016887
GO:0044183
GO:0051082
GO:0140657
GO:0140662
HMNXSV003020930
HMNXSV003048431
ILMN_1699610
PH_hs_0028950
TC17001362.hg
g5729760_3p_at
Participates
as a candidate of
CCT6 [cytosol] (Homo sapiens)
Inferred To
CCT6 [cytosol]
(Drosophila melanogaster)
CCT6 [cytosol]
(Gallus gallus)
CCT6 [cytosol]
(Saccharomyces cerevisiae)
cct6 [cytosol]
(Dictyostelium discoideum)
cct6 [cytosol]
(Schizosaccharomyces pombe)
cct6a [cytosol]
(Danio rerio)
cct6a [cytosol]
(Xenopus tropicalis)
cct-6 [cytosol]
(Caenorhabditis elegans)
Homologues of CCT6B [cytosol]
(Dictyostelium discoideum)
CCT6B [cytosol]
(Bos taurus)
CCT6B [cytosol]
(Canis familiaris)
CCT6B [cytosol]
(Dictyostelium discoideum)
CCT6B [cytosol]
(Plasmodium falciparum)
CCT6B [cytosol]
(Sus scrofa)
Cct6b [cytosol]
(Mus musculus)
Cct6b [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000436961
,
ENSP00000398044
,
ENST00000421975
,
ENSP00000327191
,
ENSP00000400917
,
ENSG00000132141
,
ENST00000314144
OpenTargets
ENSG00000132141
GeneCards
CCT6B
HPA
ENSG00000132141-CCT6B
PRO
Q92526
Pharos - Targets
Q92526
GlyGen
Q92526
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.623
3
UniProt:Q16518 RPE65
1
RPE65 [plasma membrane]
(R-HSA-74853)
0.623
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
3
UniProt:O00628 PEX7
2
PEX7 [peroxisomal membrane]
(R-HSA-9033493)
PEX7 [cytosol]
(R-HSA-9033107)
0.527
3
UniProt:Q9BQA1 WDR77
3
WDR77 [cytosol]
(R-HSA-191823)
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [nucleoplasm]
(R-HSA-5205610)
0.527
3
UniProt:Q9Y4U1 MMACHC
6
MMACHC [cytosol]
(R-HSA-2980949)
MMACHC R111* [cytosol]
(R-HSA-3318593)
MMACHC R161Q [cytosol]
(R-HSA-3318613)
MMACHC W203* [cytosol]
(R-HSA-3928672)
MMACHC R91Kfs*14 [cytosol]
(R-HSA-3318604)
MMACHC R132* [cytosol]
(R-HSA-3318572)
0.499
3
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