Reactome | PEX7 binds cargo proteins containing PTS2

PEX7 binds cargo proteins containing PTS2

Stable Identifier

R-HSA-9033232

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PEX7 binds cargo proteins containing PTS2

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Cytosolic PEX7 binds peroxisome targeting signal 2 (PTS2), a sequence of nine amino acid residues functionally identified in 3 human peroxisomal matrix proteins (Braverman et al. 1997, Motley et al. 1997, Purdue et al. 1997, Braverman et al. 2000, Ghys et al. 2002, Motley et al. 2002, Kunze et al. 2011, Kunze et al. 2015). According to molecular modeling, the PTS2 consensus sequence binds a groove in PEX7 (Kunze et al. 2011). Mutations in PEX7 cause rhizomelic chondrodysplasia punctata type 1 (Braverman et al. 1997, Motley et al. 1997, Purdue et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9090383	Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor Purdue, PE, Zhang, JW, Skoneczny, M, Lazarow, PB	Nat. Genet.	1997
11781871	Mutational spectrum in the PEX7 gene and functional analysis of mutant alleles in 78 patients with rhizomelic chondrodysplasia punctata type 1 Motley, AM, Brites, P, Gerez, L, Hogenhout, E, Haasjes, J, Benne, R, Tabak, HF, Wanders, RJA, Waterham, HR	Am. J. Hum. Genet.	2002
9090381	Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata Braverman, N, Steel, G, Obie, C, Moser, A, Moser, H, Gould, SJ, Valle, D	Nat. Genet.	1997
25538232	Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7 Kunze, M, Malkani, N, Maurer-Stroh, S, Wiesinger, C, Schmid, JA, Berger, J	J. Biol. Chem.	2015
10673331	PEX7 gene structure, alternative transcripts, and evidence for a founder haplotype for the frequent RCDP allele, L292ter Braverman, N, Steel, G, Lin, P, Moser, A, Moser, H, Valle, D	Genomics	2000
11931631	Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins Ghys, K, Fransen, M, Mannaerts, GP, Van Veldhoven, PP	Biochem. J.	2002
9090382	Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor Motley, AM, Hettema, EH, Hogenhout, EM, Brites, P, ten Asbroek, AL, Wijburg, FA, Baas, F, Heijmans, HS, Tabak, HF, Wanders, RJ, Distel, B	Nat. Genet.	1997
22057399	Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7 Kunze, M, Neuberger, G, Maurer-Stroh, S, Ma, J, Eck, T, Braverman, N, Schmid, JA, Eisenhaber, F, Berger, J	J. Biol. Chem.	2011