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Interleukin-27 signaling
Stable Identifier
R-HSA-9020956
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
General
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Interleukin-27 (IL27) is a heterodimeric cytokine that contains Epstein-Barr virus–induced gene 3 (EBI3) and IL27p28 (IL27). It signals through a receptor composed of Interleukin-6 receptor subunit beta (IL6ST, gp130), which is utilized by many cytokines, and Interleukin-27 receptor subunit alpha (IL27RA, WSX-1, TCCR) (Yoshida & Hunter 2015).
Literature References
PubMed ID
Title
Journal
Year
25861977
The immunobiology of interleukin-27
Hunter, CA
,
Yoshida, H
Annu. Rev. Immunol.
2015
Participants
Events
CANX binds EBI3
(Homo sapiens)
EBI3:CANX binds IL27
(Homo sapiens)
CANX dissociates from IL27:EBI3
(Homo sapiens)
Interleukin-27 translocates from the ER lumen to the extracellular region
(Homo sapiens)
sIL27RA translocates from the cytoplasm to the extracellular region
(Homo sapiens)
IL27RA dimerizes
(Homo sapiens)
IL27RA binds JAK1
(Homo sapiens)
JAK1,JAK2,(TYK2) bind IL6ST
(Homo sapiens)
Interleukin-27 binds Interleukin-27 receptor
(Homo sapiens)
Interleukin-27 dissociates from Interleukin-27 receptor
(Homo sapiens)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
(Homo sapiens)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
(Homo sapiens)
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
(Homo sapiens)
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
(Homo sapiens)
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
(Homo sapiens)
p-STAT1 binds p-STAT3
(Homo sapiens)
p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus
(Homo sapiens)
IL27 binds CRLF1
(Homo sapiens)
CRLF1:IL27 translocates to the extracellular region
(Homo sapiens)
IL27 translocates from the cytosol to the extracellular space
(Homo sapiens)
Participates
as an event of
Interleukin-12 family signaling (Homo sapiens)
Event Information
Go Biological Process
interleukin-27-mediated signaling pathway (0070106)
Orthologous Events
Interleukin-27 signaling (Bos taurus)
Interleukin-27 signaling (Caenorhabditis elegans)
Interleukin-27 signaling (Canis familiaris)
Interleukin-27 signaling (Dictyostelium discoideum)
Interleukin-27 signaling (Drosophila melanogaster)
Interleukin-27 signaling (Gallus gallus)
Interleukin-27 signaling (Mus musculus)
Interleukin-27 signaling (Rattus norvegicus)
Interleukin-27 signaling (Sus scrofa)
Interleukin-27 signaling (Xenopus tropicalis)
Authored
Jupe, S (2009-11-24)
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Tanaka, M (2015-11-09)
Narazaki, M (2015-11-09)
Created
Jupe, S (2017-09-12)
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