Interleukin-27 signaling

Stable Identifier
R-HSA-9020956
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Interleukin-27 signaling
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Interleukin-27 (IL27) is a heterodimeric cytokine that contains Epstein-Barr virus–induced gene 3 (EBI3) and IL27p28 (IL27). It signals through a receptor composed of Interleukin-6 receptor subunit beta (IL6ST, gp130), which is utilized by many cytokines, and Interleukin-27 receptor subunit alpha (IL27RA, WSX-1, TCCR) (Yoshida & Hunter 2015).

Literature References
PubMed ID Title Journal Year
25861977 The immunobiology of interleukin-27

Hunter, CA, Yoshida, H

Annu. Rev. Immunol. 2015
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Event Information
Go Biological Process
interleukin-27-mediated signaling pathway (0070106)
Orthologous Events
Interleukin-27 signaling (Bos taurus)
Interleukin-27 signaling (Caenorhabditis elegans)
Interleukin-27 signaling (Canis familiaris)
Interleukin-27 signaling (Danio rerio)
Interleukin-27 signaling (Dictyostelium discoideum)
Interleukin-27 signaling (Drosophila melanogaster)
Interleukin-27 signaling (Gallus gallus)
Interleukin-27 signaling (Mus musculus)
Interleukin-27 signaling (Rattus norvegicus)
Interleukin-27 signaling (Sus scrofa)
Interleukin-27 signaling (Xenopus tropicalis)
Authored
Jupe, S  (2009-11-24)
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Tanaka, M  (2015-11-09)
Narazaki, M  (2015-11-09)
Created
Jupe, S  (2017-09-12)
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