CRLF1:IL27 translocates to the extracellular region

Stable Identifier
R-HSA-8950731
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
Cytokine receptor like factor-1:Interleukin-27 subunit alpha complex translocates to the extracelular region.
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Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytokine like factor 1 (CRLF1) form a secreted complex. Secretion of IL27 was observed in HEK 293 cells transfected with IL27 cDNA in the absence of CRLF1. This may indicate that formation of a complex is not strictly required for IL27 secretion in these cells. Alternatively it could reflect the formation of a complex between IL27 and endogenous CRLF1, which is expressed in HEK 293 cells. The IL27:CRLF1 complex is biologically active (Crabé et al. 2009).

This reaction is a black box event because the mechanism of translocation is unknown.

Literature References
PubMed ID Title Journal Year
19933857 The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

Crabé, S, Guay-Giroux, A, Tormo, AJ, Duluc, D, Lissilaa, R, Guilhot, F, Mavoungou-Bigouagou, U, Lefouili, F, Cognet, I, Ferlin, W, Elson, G, Jeannin, P, Gauchat, JF

J. Immunol. 2009
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