Interleukin 27 alpha subunit (IL27,IL27A, IL27p28) and Cytokine like factor 1 (CRLF1) form a secreted complex. Secretion of IL27 was observed in HEK 293 cells transfected with IL27 cDNA in the absence of CRLF1. This may indicate that formation of a complex is not strictly required for IL27 secretion in these cells. Alternatively it could reflect the formation of a complex between IL27 and endogenous CRLF1, which is expressed in HEK 293 cells. The IL27:CRLF1 complex is biologically active (Crabé et al. 2009).This reaction is a black box event because the mechanism of translocation is unknown.
Ferlin, W, Mavoungou-Bigouagou, U, Guilhot, F, Tormo, AJ, Crabé, S, Lissilaa, R, Duluc, D, Lefouili, F, Jeannin, P, Gauchat, JF, Elson, G, Cognet, I, Guay-Giroux, A
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