Interleukin-27 translocates from the ER lumen to the extracellular region

Stable Identifier
R-HSA-448421
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
IL27:EBI3 (IL27) is secreted to the extracellular space
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When Interleukin-27 subunit beta (EBI3) was expressed in cells, it accumulated in the endoplasmic reticulum and associated with the molecular chaperone calnexin(CANX), indicating that subsequent processing and secretion might be dependent on association with a second subunit (Devergne et al.1996)
Interleukin-27 subunit alpha (IL27) coexpressed with EBI3 permitted secretion as a soluble complex (Pflanz et al. 2002)

This is a black box event because there is not reported evidene about the mechanism of the traslocation of the IL-27 heterodimer from the endoplasmic reticulum to the extracellular region.

Literature References
PubMed ID Title Journal Year
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Pflanz, S, Timans, JC, Cheung, J, Rosales, R, Kanzler, H, Gilbert, J, Hibbert, L, Churakova, T, Travis, M, Vaisberg, E, Blumenschein, WM, Mattson, JD, Wagner, JL, To, W, Zurawski, S, McClanahan, TK, Gorman, DM, Bazan, JF, de Waal Malefyt, R, Rennick, D, Kastelein, RA

Immunity 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created