IL27RA dimerizes

Stable Identifier
R-HSA-8950766
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27 receptor subunit alpha:JAK2 dimerizes
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Interleukin-27 receptor subunit alpha (IL27RA, WSX1) can interact with itself. Co-expression in HEK- 293 cells followed by immunoprecipitation with epitope tag antibodies revealed that IL27RA forms homodimers. Immunoblotting for JAK proteins and Interleukin-6 receptor beta (IL6ST, gp130) did not detect these as part of the IL27RA-containing complex (Pradhan et al. 2010).

A deletion mutation has been described to enhance homodimeric Interleukin-27 receptor formation (IL27RA/IL27RA) (Lambert et al. 2011).

Literature References
PubMed ID Title Journal Year
21631431 Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

Lambert, QT, Pradhan, A, Roll, JD, Reuther, GW

Biochem. J. 2011
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