IL27RA dimerizes

Stable Identifier
R-HSA-8950766
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-27 receptor subunit alpha:JAK2 dimerizes
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IL27RA dimerizes
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Interleukin-27 receptor subunit alpha (IL27RA, WSX1) can interact with itself. Co-expression in HEK- 293 cells followed by immunoprecipitation with epitope tag antibodies revealed that IL27RA forms homodimers. Immunoblotting for JAK proteins and Interleukin-6 receptor beta (IL6ST, gp130) did not detect these as part of the IL27RA-containing complex (Pradhan et al. 2010).

A deletion mutation has been described to enhance homodimeric Interleukin-27 receptor formation (IL27RA/IL27RA) (Lambert et al. 2011).

Literature References
PubMed ID Title Journal Year
21631431 Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

Lambert, QT, Pradhan, A, Roll, JD, Reuther, GW

Biochem. J. 2011
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Orthologous Events
IL27RA dimerizes (Bos taurus)
IL27RA dimerizes (Caenorhabditis elegans)
IL27RA dimerizes (Canis familiaris)
IL27RA dimerizes (Danio rerio)
IL27RA dimerizes (Gallus gallus)
IL27RA dimerizes (Mus musculus)
IL27RA dimerizes (Rattus norvegicus)
IL27RA dimerizes (Sus scrofa)
IL27RA dimerizes (Xenopus tropicalis)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)