Reactome | p-STAT1 binds p-STAT3

p-STAT1 binds p-STAT3

Stable Identifier

R-HSA-8950782

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Monocytes express the Interleukin-27 receptor and in response to Interleukin-27 induce Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT3 phosphorylation (Pflanz et al. 2004). Interleukin-27 can induce formation of STAT1/STAT3 heterodimers (Guzzo et al. 2010, Hirahara et al. 2015). Nuclear factor NF-kappa-B (NFkB) is activated by Interleukin-27 stimulation in response to STAT1/STAT3 activation and is essential for Interleukin-27 to activate the production of cytokines (Guzzo et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20519510	Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes Che Mat, NF, Gee, K, Guzzo, C	J. Biol. Chem.	2010
25992861	Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity O'Shea, JJ, Kanno, Y, Hunter, CA, Villarino, AV, Nakayama, T, Suzuki, R, Mikami, Y, Brooks, SR, Sun, HW, Hirahara, K, Laurence, A, Onodera, A, Sciumè, G, Okamoto, Y, Bonelli, M, Gutierrez-Cruz, G, Holland, SM, Shih, HY, Iwata, S, Vahedi, G	Immunity	2015