p-STAT1 binds p-STAT3

Stable Identifier
R-HSA-8950782
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Monocytes express the Interleukin-27 receptor and in response to Interleukin-27 induce Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT3 phosphorylation (Pflanz et al. 2004). Interleukin-27 can induce formation of STAT1/STAT3 heterodimers (Guzzo et al. 2010, Hirahara et al. 2015). Nuclear factor NF-kappa-B (NFkB) is activated by Interleukin-27 stimulation in response to STAT1/STAT3 activation and is essential for Interleukin-27 to activate the production of cytokines (Guzzo et al. 2010).

Literature References
PubMed ID Title Journal Year
25992861 Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

Hirahara, K, Onodera, A, Villarino, AV, Bonelli, M, Sciumè, G, Laurence, A, Sun, HW, Brooks, SR, Vahedi, G, Shih, HY, Gutierrez-Cruz, G, Iwata, S, Suzuki, R, Mikami, Y, Okamoto, Y, Nakayama, T, Holland, SM, Hunter, CA, Kanno, Y, O'Shea, JJ

Immunity 2015
20519510 Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes

Guzzo, C, Che Mat, NF, Gee, K

J. Biol. Chem. 2010
Participants
Participant Of
Orthologous Events
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Created