Interleukin-27 dissociates from Interleukin-27 receptor

Stable Identifier
R-HSA-8950210
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Interleukin-27 heterodimer (IL27) binds a heterodimeric receptor formed by Interleukin-27 subunit alpha (IL27RA) and Interleukin-6 receptor subunit beta (IL6ST, gp130). In the absence of IL27RA IL27 can bind IL6ST with low affinity. Dissociation rate constants for binding of IL27 to the heterodimeric receptor indicate a slow dissociation rate, resulting in very high binding affinity. Blocking both receptor chains completely blocks IL27 induced STAT1 and STAT3 phosphorylation and IL27 induced proliferation (Jia et al. 2016).

Literature References
PubMed ID Title Journal Year
27119567 IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs

Jia, H, Dilger, P, Bird, C, Wadhwa, M

J. Interferon Cytokine Res. 2016
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