Interleukin-27 dissociates from Interleukin-27 receptor

Stable Identifier
R-HSA-8950210
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
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Interleukin-27 dissociates from Interleukin-27 receptor
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Interleukin-27 heterodimer (IL27) binds a heterodimeric receptor formed by Interleukin-27 subunit alpha (IL27RA) and Interleukin-6 receptor subunit beta (IL6ST, gp130). In the absence of IL27RA IL27 can bind IL6ST with low affinity. Dissociation rate constants for binding of IL27 to the heterodimeric receptor indicate a slow dissociation rate, resulting in very high binding affinity. Blocking both receptor chains completely blocks IL27 induced STAT1 and STAT3 phosphorylation and IL27 induced proliferation (Jia et al. 2016).
Literature References
PubMed ID Title Journal Year
27119567 IL-27 Promotes Proliferation of Human Leukemic Cell Lines Through the MAPK/ERK Signaling Pathway and Suppresses Sensitivity to Chemotherapeutic Drugs

Wadhwa, M, Dilger, P, Bird, C, Jia, H

J. Interferon Cytokine Res. 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL27 [extracellular region] (Homo sapiens)
Orthologous Events
Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)
Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)
Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)
Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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