Inferred from mouse: The cytoplasmic domain of Interleukin-27 receptor subunit alpha (Il27ra) has a Box-1 motif which is important for binding to the Janus kinase family of proteins (Sprecher et al. 1998). Mouse Interleukin-27 receptor alpha (Il27ra, WSX-1) has been shown to directly associate with Tyrosine-protein kinase JAK1 (Jak1) as well as Signal transducer and activator of transcription 1-alpha/beta (Stat1) . Coimmunoprecipitation studies and pull-down assays suggest that the Il27ra directly associates with Jak1 and that one of its tyrosine residues provides a docking site for Stat1 when phosphorylated (Takeda et al. 2003).
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