IL27 translocates from the cytosol to the extracellular space

Stable Identifier
R-HSA-8950674
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27 subunit alpha traslocates to the extracellular region
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Inferred from mouse:
Experiments in cells transfected with mouse Interleukin 27 subunit beta (Ebi3) and Interleukin 27 subunit alpha (Il27, IL27p28) showed that Il27 can be secreted as a monomer, whereas mouse Ebi3 protein is secreted only as heterodimers with Il27 (Shimozato et al. 2009). Il27, independently of Ebi3, can antagonize cytokine signaling through Interleukin 6 receptor subunit beta (Il6st, gp130) and Interleukin 6 (Il6) mediated production of Interleukin 17 (Il17) and Interleukin 10 (Il10) (Stumhofer et al. 2010).

This reaction is a black box event because the mechanism of Il27 translocation is unknown.

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