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IL27 translocates from the cytosol to the extracellular space
Stable Identifier
R-HSA-8950674
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
Synonyms
Interleukin-27 subunit alpha traslocates to the extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27 translocates from the cytosol to the extracellular space (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inferred from mouse:
Experiments in cells transfected with mouse Interleukin 27 subunit beta (Ebi3) and Interleukin 27 subunit alpha (Il27, IL27p28) showed that Il27 can be secreted as a monomer, whereas mouse Ebi3 protein is secreted only as heterodimers with Il27 (Shimozato et al. 2009). Il27, independently of Ebi3, can antagonize cytokine signaling through Interleukin 6 receptor subunit beta (Il6st, gp130) and Interleukin 6 (Il6) mediated production of Interleukin 17 (Il17) and Interleukin 10 (Il10) (Stumhofer et al. 2010).
This reaction is a black box event because the mechanism of Il27 translocation is unknown.
Participants
Input
IL27 [cytosol]
(Homo sapiens)
Output
IL27 [extracellular region]
(Homo sapiens)
Participates
as an event of
Interleukin-27 signaling (Homo sapiens)
Inferred From
Interleukin 27 translocates to the extracellular region (Mus musculus)
Authored
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Created
Duenas, C (2016-12-02)
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