JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated

Stable Identifier
R-HSA-8950537
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Interleukin 27 phosphorylates/activates Tyrosine protein kinase JAK2 (JAK2) , non receptor tyrosine protein kinase TYK2 (TYK2) and Tyrosine protein kinase JAK1 (JAK1) (Kanda & Watanabe 2008). JAK1 interacts with IL27RA (Takeda et al 2003 )
As the phosphorylation required for Interleukin 27 induced activation are not clear, this is represented here as a black box event.

Literature References
PubMed ID Title Journal Year
18389480 IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

Kanda, N, Watanabe, S

Eur. J. Immunol. 2008
Participants
Participates
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane]

Orthologous Events
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