IL27 binds CRLF1

Stable Identifier
R-HSA-8950504
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27 subunit alpha binds Cytokine-like factor 1
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Interleukin 27 alpha subunit (IL27, IL 27p28) can bind Cytokine receptor like factor 1 (CRLF1). IL27 has greatest homology with Interleukin 11 (IL11) and CRLF1. The IL27:CRLF1 complex is produced in dendritic cells and stimulates Natural Killer (NK) cells, increasing Interleukin 12 and Interleukin 2 induced Interferon gamma (IFNG) production and activation of marker expression.

Experiments with Ba/F3 transfectants indicate that IL27:CRLF1 activates cells expressing Interleukin 6 receptor subunit alpha (IL6R) in addition to the Interleukin 27 receptor subunits WSX1 and gp130. When tested on CD4+ and CD8+ T cells, IL27:CRLF1 induces Interleukin 6 receptor subunit alpha (IL6RA) dependent Signal transducer and activator of transcription 1 alpha/beta (STAT1) and STAT3 phosphorylation (Crabé et al. 2009). This reaction is a Black Box event since we know this complex forms and is secreted but do not know the compartment where dimer formation takes place.

Literature References
PubMed ID Title Journal Year
19933857 The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

Crabé, S, Guay-Giroux, A, Tormo, AJ, Duluc, D, Lissilaa, R, Guilhot, F, Mavoungou-Bigouagou, U, Lefouili, F, Cognet, I, Ferlin, W, Elson, G, Jeannin, P, Gauchat, JF

J. Immunol. 2009
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