Reactome | IL27 binds CRLF1

IL27 binds CRLF1

Stable Identifier

R-HSA-8950504

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interleukin-27 subunit alpha binds Cytokine-like factor 1

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin 27 alpha subunit (IL27, IL 27p28) can bind Cytokine receptor like factor 1 (CRLF1). IL27 has greatest homology with Interleukin 11 (IL11) and CRLF1. The IL27:CRLF1 complex is produced in dendritic cells and stimulates Natural Killer (NK) cells, increasing Interleukin 12 and Interleukin 2 induced Interferon gamma (IFNG) production and activation of marker expression.

Experiments with Ba/F3 transfectants indicate that IL27:CRLF1 activates cells expressing Interleukin 6 receptor subunit alpha (IL6R) in addition to the Interleukin 27 receptor subunits WSX1 and gp130. When tested on CD4+ and CD8+ T cells, IL27:CRLF1 induces Interleukin 6 receptor subunit alpha (IL6RA) dependent Signal transducer and activator of transcription 1 alpha/beta (STAT1) and STAT3 phosphorylation (Crabé et al. 2009). This reaction is a Black Box event since we know this complex forms and is secreted but do not know the compartment where dimer formation takes place.

Literature References

PubMed ID	Title	Journal	Year
19933857	The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling Ferlin, W, Mavoungou-Bigouagou, U, Guilhot, F, Tormo, AJ, Crabé, S, Lissilaa, R, Duluc, D, Lefouili, F, Jeannin, P, Gauchat, JF, Elson, G, Cognet, I, Guay-Giroux, A	J. Immunol.	2009