Reactome | CTLH E3 ligase ubiquitinates PKM-1

CTLH E3 ligase ubiquitinates PKM-1

Stable Identifier

R-HSA-9861640

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CTLH E3 ligase complex transfers multiple ubiquitin (Ub) units onto PKM-1 (PKM2), inhibiting pyruvate kinase activity. Which E2 enzyme and which ubiquitin linkage type are involved in these ubiquitination events remain an open question (Maitland et al., 2021). The CTLH complex consists of the proteins ARMC8, GID4, Muskelin, GID8, RANBP9, WDR26, and the catalytic subunits RMND5A or RMND5B and MAEA (Lampert et al., 2018; Maitland et al., 2019).

Literature References

PubMed ID	Title	Journal	Year
31285494	The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation Schild-Poulter, C, Shaw, GS, Moor, SE, Onea, G, Chiasson, CA, Lajoie, GA, Ma, J, Maitland, MER, Barber, KR, Wang, X	Sci Rep	2019
34383978	Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis Schild-Poulter, C, Kuljanin, M, Lajoie, GA, Maitland, MER, Wang, X	FASEB J	2021
29911972	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation Goga, A, Olieric, N, Stafa, D, Peter, M, Picotti, P, Stoffel, M, Soste, MV, Gilberto, S, Lampert, F	Elife	2018