Reactome | TINF2 [nucleoplasm]

TINF2 [nucleoplasm]

Stable Identifier

R-HSA-174883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TIN2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Telomere shortening during replicative exhaustion (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BSI4 TINF2

Gene Names

TINF2, TIN2

Chain

initiator methionine:1, chain:2-451

Reference Genes

BioGPS Gene:26277 TINF2

COSMIC (genes):TINF2 TINF2

CTD Gene:26277 TINF2

dbSNP Gene:26277 TINF2

ENSEMBL:ENSG00000092330 TINF2

ENSEMBL:ENSG00000092330.19 TINF2

ENSEMBL:ENSG00000284915.3 TINF2

HGNC:11824 TINF2

KEGG Gene (Homo sapiens):26277 TINF2

Monarch:26277 TINF2

NCBI Gene:26277 TINF2

OMIM:604319 TINF2

UCSC:Q9BSI4 TINF2

Reference Transcript

Other Identifiers

11715868_a_at

11715869_x_at

11729448_a_at

11729449_s_at

16791197

220052_PM_s_at

220052_s_at

223776_PM_x_at

223776_x_at

224809_PM_x_at

224809_x_at

26277

3558014

3558015

3558016

3558017

3558018

3558019

3558020

3558021

3558022

3558023

3558024

3558026

3558028

3558030

3558032

3558035

3558036

3558037

57237_at

7978208

A_23_P77020

A_33_P3372941

GE81801

GO:0000781

GO:0000783

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0010370

GO:0010836

GO:0016233

GO:0016363

GO:0016604

GO:0032200

GO:0032202

GO:0032206

GO:0032211

GO:0036211

GO:0042162

GO:0043226

GO:0050680

GO:0070187

GO:0070198

GO:1904356

HMNXSV003008274

HMNXSV003011750

Hs.7797.2.A1_3p_a_at

Hs.7797.2.A1_3p_x_at

PH_hs_0000805

TC14000970.hg

g13477144_3p_a_at

Participates

as a component of

Inferred To

Ghost homologue of TINF2 [nucleoplasm] (Gallus gallus)

Tinf2 [nucleoplasm] (Mus musculus)

Tinf2 [nucleoplasm] (Rattus norvegicus)

TINF2 [nucleoplasm] (Bos taurus)

TINF2 [nucleoplasm] (Canis familiaris)

TINF2 [nucleoplasm] (Danio rerio)

TINF2 [nucleoplasm] (Sus scrofa)

tinf2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001092744.1, NP_036593.2

OpenTargets

ENSG00000092330

HPA

ENSG00000092330-TINF2

GeneCards

Q9BSI4

Ensembl

ENST00000399423, ENST00000646576, ENSP00000267415, ENST00000642983, ENST00000267415, ENSG00000092330, ENSP00000382350, ENSG00000284915, ENSP00000495019, ENSP00000494089

PRO

Q9BSI4

Pharos - Targets

Q9BSI4

Orphanet

16938

PDB

3BU8, 5XYF, 3BQO

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.547	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.508	2
UniProt:O60907 TBL1X	1	TBL1X [nucleoplasm] (R-HSA-351644)	0.508	2
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.508	2
UniProt:P05771 PRKCB	5	p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500-PRKCB [cytosol] (R-HSA-5218728) PRKCB [cytosol] (R-HSA-58198) PRKCB [plasma membrane] (R-HSA-156467)	0.508	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.508	2
UniProt:P50542 PEX5	4	p-PEX5 [peroxisomal membrane] (R-HSA-9665182) Ub-p-PEX5 [peroxisomal membrane] (R-HSA-9665183) PEX5 [peroxisomal membrane] (R-HSA-9665164) PEX5 [cytosol] (R-HSA-9033132)	0.508	2
UniProt:P23588 EIF4B	2	p-S422-EIF4B [cytosol] (R-HSA-165773) EIF4B [cytosol] (R-HSA-72589)	0.508	2
UniProt:O43602 DCX	1	DCX [cytosol] (R-HSA-430060)	0.508	2

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