Reactome | SUPT6H [nucleoplasm]

SUPT6H [nucleoplasm]

Stable Identifier

R-HSA-8932908

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription elongation factor SPT6, SPT6H_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q7KZ85 SUPT6H

Gene Names

SUPT6H, KIAA0162, SPT6H

Chain

initiator methionine:, chain:2-1726

Reference Genes

BioGPS Gene:6830 SUPT6H

COSMIC (genes):SUPT6H SUPT6H

CTD Gene:6830 SUPT6H

dbSNP Gene:6830 SUPT6H

ENSEMBL:ENSG00000109111 SUPT6H

HGNC:11470 SUPT6H

KEGG:hsa:6830 SUPT6H

Monarch:6830 SUPT6H

NCBI Gene:6830 SUPT6H

OMIM:601333 SUPT6H

UCSC:Q7KZ85 SUPT6H

Reference Transcript

Other Identifiers

11743445_a_at

11743446_x_at

11746726_a_at

11747687_a_at

1554311_PM_a_at

1554311_a_at

16832518

208420_PM_x_at

208420_x_at

208830_PM_s_at

208830_s_at

208831_PM_x_at

208831_x_at

3715704

3715711

3715713

3715714

3715715

3715716

3715717

3715718

3715719

3715720

3715721

3715722

3715723

3715724

3715725

3715726

3715728

3715729

3715730

3715731

3715732

3715733

3715734

3715736

3715738

3715739

3715740

3715741

3715742

3715743

3715744

3715745

3715746

3715747

3715748

3715749

3715750

3715751

3715753

3715754

3715755

3715756

3715757

3715758

3715760

3715761

3715762

3715763

3715764

3715765

3715766

3715767

3715768

41659_at

6830

8005903

A_14_P117539

A_23_P141479

A_24_P126873

D79984_s_at

GE81243

GO:0001825

GO:0003676

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0006139

GO:0006325

GO:0006351

GO:0006355

GO:0006366

GO:0006368

GO:0006397

GO:0008023

GO:0008380

GO:0010793

GO:0016071

GO:0031491

GO:0032968

GO:0034728

GO:0042393

GO:0043226

GO:0045191

GO:0050684

GO:0051028

GO:0051147

GO:0140673

HMNXSV003031822

Hs.12303.1.S1_3p_s_at

ILMN_1758717

PH_hs_0032323

TC17000325.hg

TC17002145.hg

g1136385_3p_a_at

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Recruitment of elongation factors to form elongation complex (Homo sapiens)

Inferred To

supt6h [nucleoplasm] (Xenopus tropicalis)

spt6 [nucleoplasm] (Dictyostelium discoideum)

spt6 [nucleoplasm] (Schizosaccharomyces pombe)

SUPT6H [nucleoplasm] (Bos taurus)

SUPT6H [nucleoplasm] (Canis familiaris)

SUPT6H [nucleoplasm] (Gallus gallus)

SUPT6H [nucleoplasm] (Sus scrofa)

Spt6 [nucleoplasm] (Drosophila melanogaster)

emb-5 [nucleoplasm] (Caenorhabditis elegans)

Supt6h [nucleoplasm] (Mus musculus)

Supt6h [nucleoplasm] (Rattus norvegicus)

SPT6 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000109111

ENSEMBL

ENSP00000319104, ENST00000314616, ENSG00000109111, ENSP00000338143, ENST00000347486

HPA

ENSG00000109111-SUPT6H

GeneCards

SUPT6H

PRO

Q7KZ85

Pharos - Targets

Q7KZ85

GlyGen

Q7KZ85

PDB

7UND, 8OF0, 7UNC, 7OOP, 6GME, 8OEU, 7OPC, 6TED, 6GMH, 7OPD, 8OEV

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.643	3
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:P61218 POLR2F	2	POLR2F [cytosol] (R-HSA-1964441) POLR2F [nucleoplasm] (R-HSA-83714)	0.527	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.527	2
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.527	2
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.527	3
UniProt:Q9NWS0 PIHD1			0.527	2
UniProt:Q6DKI7 PVRIG			0.527	2
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	3

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