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RPRD2 [nucleoplasm]
Stable Identifier
R-HSA-6814906
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Regulation of nuclear pre-mRNA domain-containing protein 2, RPRD2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
RPRD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5VT52 RPRD2
Gene Names
RPRD2, KIAA0460, HSPC099
Chain
initiator methionine:, chain:2-1461
Reference Genes
BioGPS Gene:23248 RPRD2
COSMIC (genes):RPRD2 RPRD2
CTD Gene:23248 RPRD2
dbSNP Gene:23248 RPRD2
ENSEMBL:ENSG00000163125 RPRD2
HGNC:29039 RPRD2
KEGG:hsa:23248 RPRD2
Monarch:23248 RPRD2
NCBI Gene:23248 RPRD2
OMIM:614695 RPRD2
UCSC:Q5VT52 RPRD2
Reference Transcript
RefSeq:NM_001297674.1 RPRD2
RefSeq:NM_001297673.1 RPRD2
RefSeq:NM_015203.4 RPRD2
Other Identifiers
11719593_at
11746513_a_at
11747557_a_at
16670527
212553_PM_at
212553_at
226527_PM_at
226527_at
23248
235415_PM_at
235415_at
2358222
2358223
2358224
2358225
2358226
2358227
2358228
2358241
2358244
2358257
2358258
2358259
2358260
2358261
2358262
2358263
2358266
2358271
2358272
2358273
2358274
2358275
2358277
2358278
2358281
2358282
2358283
2358284
2358285
2358286
2358287
2358288
2358289
2358290
2358291
2358292
2358293
2358294
35244_at
46127_at
62920_at
75660_at
7905185
A_14_P202263
A_23_P60657
A_33_P3381781
GE497073
GE53200
GO:0000993
GO:0005654
GO:0016071
GO:0031124
GO:0097550
GO:0099122
HMNXSV003028751
HMNXSV003040734
HMNXSV003044077
Hs.155548.0.A1_3p_at
Hs.29956.0.A1_3p_at
Hs.29956.0.A1_3p_x_at
Hs.5669.0.A1_3p_at
ILMN_1705733
PH_hs_0002582
TC01001186.hg
TC01004733.hg
Participates
as an output of
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
as a component of
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
as an input of
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
Inferred To
RTT103 [nucleoplasm]
(Saccharomyces cerevisiae)
rprd2a [nucleoplasm]
(Danio rerio)
Ghost homologue of RPRD2 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of RPRD2 [nucleoplasm]
(Dictyostelium discoideum)
Rprd2 [nucleoplasm]
(Mus musculus)
Rprd2 [nucleoplasm]
(Rattus norvegicus)
RPRD2 [nucleoplasm]
(Bos taurus)
RPRD2 [nucleoplasm]
(Canis familiaris)
RPRD2 [nucleoplasm]
(Gallus gallus)
RPRD2 [nucleoplasm]
(Schizosaccharomyces pombe)
RPRD2 [nucleoplasm]
(Sus scrofa)
rprd2 [nucleoplasm]
(Xenopus tropicalis)
Dmel\CG15160 [nucleoplasm]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000358064
,
ENST00000369067
,
ENST00000369068
,
ENST00000401000
,
ENSP00000358063
,
ENSP00000383785
OpenTargets
ENSG00000163125
HPA
ENSG00000163125-RPRD2
PRO
Q5VT52
Pharos - Targets
Q5VT52
GlyGen
Q5VT52
PDB
4FLB
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQG5 RPRD1B
1
RPRD1B [nucleoplasm]
(R-HSA-6814894)
0.527
3
UniProt:P0CAP2 GRL1A
0.527
2
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.527
2
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
0.483
2
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