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VAMP4 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Vesicle-associated membrane protein 4, VAMP-4
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75379 VAMP4
Gene Names
VAMP4
Chain
chain:1-141
Reference Genes
BioGPS Gene:8674 VAMP4
COSMIC (genes):VAMP4 VAMP4
CTD Gene:8674 VAMP4
dbSNP Gene:8674 VAMP4
ENSEMBL:ENSG00000117533 VAMP4
ENSEMBL_homo_sapiens_GENE:ENSG00000117533.15 VAMP4
HGNC:12645 VAMP4
KEGG Gene (Homo sapiens):8674 VAMP4
Monarch:8674 VAMP4
NCBI Gene:8674 VAMP4
OMIM:606909 VAMP4
UCSC:O75379 VAMP4
Reference Transcript
RefSeq:NM_003762.4 VAMP4
RefSeq:NM_001185127.1 VAMP4
Other Identifiers
11735117_at
11735118_at
11757701_s_at
11760288_s_at
11760289_a_at
11763324_a_at
16696373
207350_PM_s_at
207350_s_at
211760_PM_s_at
211760_s_at
213480_PM_at
213480_at
2443990
2443991
2443992
2443993
2443994
2443995
2443996
2443997
2443998
2443999
2444001
2444003
2444006
2444007
2444008
2444011
2444012
2444013
2444015
2444016
2444017
2444018
36818_at
37119_at
7922309
84216_at
85151_at
8674
A_23_P61569
A_24_P942030
A_33_P3409904
GE54445
GE56113
GO:0000139
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005802
GO:0005886
GO:0009986
GO:0016020
GO:0016189
GO:0016192
GO:0030133
GO:0030669
GO:0031201
GO:0031410
GO:0032456
GO:0032588
GO:0035493
GO:0043226
GO:0061024
GO:0065003
GO:0090161
GO:1900242
HMNXSV003047650
Hs.6651.0.S1_3p_at
ILMN_1664175
ILMN_1761363
ILMN_1804676
PH_hs_0000666
TC01003518.hg
TC01005934.hg
g13543647_3p_s_at
g4507862_3p_s_at
Participates
as an output of
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
as a component of
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
VAMP4 [transport vesicle]
VAMP4 [plasma membrane]
VAMP4 [clathrin-coated endocytic vesicle membrane]
Inferred To
Vamp4 [trans-Golgi network membrane]
(Mus musculus)
Vamp4 [trans-Golgi network membrane]
(Rattus norvegicus)
vamp4 [trans-Golgi network membrane]
(Xenopus tropicalis)
VAMP4 [trans-Golgi network membrane]
(Bos taurus)
VAMP4 [trans-Golgi network membrane]
(Canis familiaris)
VAMP4 [trans-Golgi network membrane]
(Gallus gallus)
VAMP4 [trans-Golgi network membrane]
(Sus scrofa)
Ghost homologue of VAMP4 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Ghost homologue of VAMP4 [trans-Golgi network membrane]
(Dictyostelium discoideum)
Ghost homologue of VAMP4 [trans-Golgi network membrane]
(Drosophila melanogaster)
Ghost homologue of VAMP4 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
Ghost homologue of VAMP4 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_003753.2
,
NP_001172056.1
OpenTargets
ENSG00000117533
GeneCards
O75379
HPA
ENSG00000117533-VAMP4
Ensembl
ENST00000367740
,
ENSP00000236192
,
ENST00000474047
,
ENSP00000435933
,
ENST00000236192
,
ENSG00000117533
,
ENSP00000356714
PRO
O75379
Pharos - Targets
O75379
HMDB Protein
HMDBP08098
Interactors (50)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.831
8
UniProt:Q86Y82 STX12
0.711
7
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.669
4
UniProt:Q9UNK0 STX8
0.643
5
UniProt:O15400 STX7
0.643
5
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.643
5
UniProt:Q5SQN1 SNP47
0.564
3
UniProt:Q5T700 LRAD1
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
IntAct:EBI-23641393 CCSB ORF ID
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:P34910-2 P349102
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:O14684 PTGES
1
PTGES [endoplasmic reticulum membrane]
(R-HSA-2142717)
0.556
3
UniProt:P00387 CYB5R3
3
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q86VR2 RETR3
0.556
3
UniProt:Q8N9I0 SYT2
3
SYT2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869116)
SYT2 [plasma membrane]
(R-HSA-168795)
SYT2 [synaptic vesicle membrane]
(R-HSA-194786)
0.556
3
UniProt:Q96DZ7 T4S19
0.556
3
UniProt:Q68DC2 ANKS6
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q6UW68 TM205
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:O14662-5 STX16
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q9NW97 TMM51
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q9BY50 SEC11C
1
SEC11C [endoplasmic reticulum membrane]
(R-HSA-265065)
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [specific granule membrane]
(R-HSA-6799569)
0.556
3
UniProt:Q9NR31 SAR1A
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:A8MZ59 LEUTX
1
LEUTX [nucleoplasm]
(R-HSA-9817277)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q8N5K1 CISD2
0.556
3
UniProt:Q96AJ9 VTI1A
2
VTI1A [trans-Golgi network membrane]
(R-HSA-6813927)
VTI1A [Golgi membrane]
(R-HSA-6811035)
0.527
3
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.527
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.527
3
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.527
3
UniProt:P0DTD8 NS7B
0.527
2
UniProt:O60499 STX10
1
STX10 [trans-Golgi network membrane]
(R-HSA-6810999)
0.527
3
UniProt:Q13190 STX5
5
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [cytosol]
(R-HSA-9613991)
0.527
3
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