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VTI1A [trans-Golgi network membrane]
Stable Identifier
R-HSA-6813927
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Vesicle transport through interaction with t-SNAREs homolog 1A, Vesicle transport v-SNARE protein Vti1-like 2, Vti1-rp2
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
VTI1A [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96AJ9 VTI1A
Gene Names
VTI1A
Chain
chain:1-217
Reference Genes
BioGPS Gene:143187 VTI1A
COSMIC (genes):VTI1A VTI1A
CTD Gene:143187 VTI1A
dbSNP Gene:143187 VTI1A
ENSEMBL:ENSG00000151532 VTI1A
ENSEMBL_homo_sapiens_GENE:ENSG00000151532.15 VTI1A
HGNC:17792 VTI1A
KEGG Gene (Homo sapiens):143187 VTI1A
Monarch:143187 VTI1A
NCBI Gene:143187 VTI1A
OMIM:614316 VTI1A
UCSC:Q96AJ9 VTI1A
Reference Transcript
RefSeq:NM_145206.3 VTI1A
RefSeq:NM_001318205.1 VTI1A
RefSeq:XM_005269544.4 VTI1A
RefSeq:NM_001318203.1 VTI1A
Other Identifiers
11727932_at
11727933_at
11759983_at
143187
1552536_PM_at
1552536_at
16709298
235034_PM_at
235034_at
235923_PM_at
235923_at
236849_3p_at
236849_PM_at
236849_at
3264397
3264398
3264399
3264400
3264407
3264408
3264420
3264427
3264468
3264469
3264484
3264485
3264510
3264511
3264512
3264513
3264514
3264515
3264516
3264517
3264518
46390_at
64181_at
79091_at
7930524
81642_at
A_14_P100357
A_23_P425932
A_32_P36313
GE675434
GO:0000139
GO:0000149
GO:0005484
GO:0005515
GO:0005737
GO:0005768
GO:0005773
GO:0005776
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006886
GO:0006888
GO:0006891
GO:0006896
GO:0006914
GO:0008021
GO:0012505
GO:0012507
GO:0015031
GO:0016020
GO:0016189
GO:0016192
GO:0016236
GO:0030136
GO:0031201
GO:0031410
GO:0031902
GO:0032456
GO:0032588
GO:0042147
GO:0043025
GO:0043226
GO:0043231
GO:0044306
GO:0048280
GO:0048471
GO:0050877
GO:0050882
GO:0060090
GO:0061024
GO:0098686
HMNXSV003041054
Hs.158622.0.A1_3p_at
Hs.189575.0.S1_3p_at
Hs.310859.0.A1_3p_at
Hs.310859.0.A1_3p_s_at
Hs.310859.0.A1_3p_x_at
Hs2.189575.1.S1_3p_at
ILMN_1810848
PH_hs_0026642
TC10002292.hg
Participates
as an output of
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
as a component of
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
VTI1A [Golgi membrane]
Inferred To
Vti1a [trans-Golgi network membrane]
(Drosophila melanogaster)
Vti1a [trans-Golgi network membrane]
(Mus musculus)
Vti1a [trans-Golgi network membrane]
(Rattus norvegicus)
vti-1 [trans-Golgi network membrane]
(Caenorhabditis elegans)
vti1A [trans-Golgi network membrane]
(Dictyostelium discoideum)
vti1 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
VTI1A [trans-Golgi network membrane]
(Bos taurus)
VTI1A [trans-Golgi network membrane]
(Canis familiaris)
VTI1A [trans-Golgi network membrane]
(Gallus gallus)
VTI1A [trans-Golgi network membrane]
(Sus scrofa)
vti1a [trans-Golgi network membrane]
(Xenopus tropicalis)
VTI1 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_660207.2
,
NP_001305134.1
,
XP_005269601.1
,
NP_001305132.1
OpenTargets
ENSG00000151532
GeneCards
Q96AJ9
HPA
ENSG00000151532-VTI1A
Ensembl
ENSG00000151532
,
ENSP00000395017
,
ENST00000393077
,
ENST00000432306
,
ENSP00000376792
PRO
Q96AJ9
Pharos - Targets
Q96AJ9
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86Y82 STX12
0.774
8
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.643
3
UniProt:P0DTD8 NS7B
0.643
3
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.569
3
UniProt:Q9UNK0 STX8
0.527
4
UniProt:Q99747 NAPG
1
NAPG [cytosol]
(R-HSA-5688555)
0.527
2
UniProt:O95183 VAMP5
0.527
3
UniProt:Q9NRW7 VPS45
2
VPS45 [Golgi membrane]
(R-HSA-6811025)
VPS45 [endosome membrane]
(R-HSA-1011607)
0.527
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.527
2
UniProt:O75379 VAMP4
4
VAMP4 [transport vesicle]
(R-HSA-6811023)
VAMP4 [trans-Golgi network membrane]
(R-HSA-6811021)
VAMP4 [plasma membrane]
(R-HSA-8864461)
VAMP4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869133)
0.527
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.527
3
UniProt:P04578-PRO_0000038428 ENV
0.462
2
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