Reactome | PTGES [endoplasmic reticulum membrane]

PTGES [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-2142717

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Prostaglandin E synthase, PTGES_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14684 PTGES

Gene Names

PTGES, MGST1L1, MPGES1, PGES, PIG12

Chain

chain:1-152

Reference Genes

BioGPS Gene:9536 PTGES

COSMIC (genes):PTGES PTGES

CTD Gene:9536 PTGES

dbSNP Gene:9536 PTGES

ENSEMBL:ENSG00000148344 PTGES

ENSEMBL_homo_sapiens_GENE:ENSG00000148344.11 PTGES

HGNC:9599 PTGES

KEGG Gene (Homo sapiens):9536 PTGES

Monarch:9536 PTGES

NCBI Gene:9536 PTGES

OMIM:605172 PTGES

UCSC:O14684 PTGES

Reference Transcript

RefSeq:NM_004878.4 PTGES

Other Identifiers

11747186_a_at

11747187_x_at

11754526_a_at

17099076

207388_PM_s_at

207388_s_at

210367_PM_s_at

210367_s_at

3227071

3227072

3227073

3227074

3227080

3227081

3227085

3227086

38131_at

56392_at

8164580

9536

A_24_P403417

GE55312

GO:0001516

GO:0003824

GO:0004364

GO:0004602

GO:0004667

GO:0005515

GO:0005634

GO:0005635

GO:0005641

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0006631

GO:0006633

GO:0006693

GO:0006954

GO:0007165

GO:0008283

GO:0008285

GO:0016020

GO:0016209

GO:0016491

GO:0016740

GO:0016853

GO:0019233

GO:0023052

GO:0031620

GO:0032308

GO:0043226

GO:0043295

GO:0048471

GO:0050220

GO:0050727

GO:0050877

GO:0098754

GO:0098869

HMNXSV003041932

ILMN_1713829

PH_hs_0008761

TC09001653.hg

g2415307_3p_a_at

g4758909_3p_a_at

Participates

as a component of

PTGES trimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

CG5579 [endoplasmic reticulum membrane] (Drosophila melanogaster)

ptges [endoplasmic reticulum membrane] (Danio rerio)

ptges [endoplasmic reticulum membrane] (Xenopus tropicalis)

Mgstl [endoplasmic reticulum membrane] (Drosophila melanogaster)

PTGES [endoplasmic reticulum membrane] (Bos taurus)

PTGES [endoplasmic reticulum membrane] (Canis familiaris)

PTGES [endoplasmic reticulum membrane] (Gallus gallus)

PTGES [endoplasmic reticulum membrane] (Mus musculus)

PTGES [endoplasmic reticulum membrane] (Rattus norvegicus)

PTGES [endoplasmic reticulum membrane] (Sus scrofa)

Homologues of PTGES [endoplasmic reticulum membrane] (Drosophila melanogaster)

Dmel\CG33177 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_004869.1

Guide to Pharmacology - Targets

1377

OpenTargets

ENSG00000148344

ZINC - Substances

PTGES_HUMAN

ZINC target

O14684

ZINC - Biogenic

PTGES_HUMAN

PRO

O14684

PDB

5T36, 8PYV, 4YL1, 5K0I, 5T37, 4YL0, 4YK5, 3DWW, 4YL3, 4AL0, 5BQG, 4BPM, 5BQI, 6VL4, 5BQH, 4AL1, 5TL9, 4WAB

ZINC - Investigational

PTGES_HUMAN

ZINC - Metabolites

PTGES_HUMAN

IntEnz

2.5.1.18

HPA

ENSG00000148344-PTGES

GeneCards

O14684

Ensembl

ENST00000340607, ENSG00000148344, ENSP00000342385

Pharos - Targets

O14684

ZINC - Predictions - Purchasable

PTGES_HUMAN

HMDB Protein

HMDBP00079

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [transport vesicle] (R-HSA-6808719)	0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3

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